Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment.

Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Abstract Text:

Tetsuya Sano,Shunji Kurotobi,Kouji Matsuzaki,Takehisa Yamamoto,Ichiro Maki,Kazunori Miki,Shigetoyo Kogaki,Junichi Hara,

Clinical, laboratory, and echocardiographic data were retrospectively analyzed in 112 patients with acute Kawasaki disease who received high-dose (2 g/kg) intravenous gamma-globulin (IVIG) treatment within 2 days and were compared for those who were responsive and non-responsive to initial IVIG treatment. Coronary arteries adjusted for body surface area (BSA) were evaluated quantitatively by comparison with the mean dimensions for 85 normal control subjects. The incidence of coronary abnormalities was higher in IVIG-non-responsive patients as compared to IVIG-responsive patients (71% versus 5%, p<0.0001). Univariate analysis of pre-IVIG data showed that the neutrophil count and serum levels of C-reactive protein (CRP), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase, and lactate dehydrogenase (LDH) were significantly higher in IVIG-non-responsive versus responsive patients. Multivariate analysis selected CRP (p=0.009), TB (p<0.001), and AST (p=0.002) as independent predictors of non-responsiveness to initial IVIG treatment. By defining predictive values, patients with at least two of three predictors (CRP>or=7.0 mg, TB>or=0.9 mg, or AST>or=200 IU/L) are considered to be non-responsive to IVIG for acute Kawasaki disease. Alternatively, more intense initial therapy may be a promising therapeutic strategy for patients who are predicted to be IVIG-non-responsive.

Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Publishing Authors By Initials

T Sano,S Kurotobi,K Matsuzaki,T Yamamoto,I Maki,K Miki,S Kogaki,J Hara,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pediatrics

VOLUME: 166

Page Numbers: 131-7

Journal Abbreviation: Eur. J. Pediatr.

ISSN: 0340-6199

DAY: 1

MONTH: 08

YEAR: 2006

Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603873

Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment.

AFFILIATION: Department of Pediatrics, Osaka Kosei-Nenkin Hospital, 4-2-78 Fukushima, Fukushima-ku, Osaka City, Osaka 553-0003, Japan. sanotet@okn.gr.jp

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Pediatr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment Related Publications

• A method to provide magnet-free long straight sections in low-emittance synchrotron radiation sources.
• Absolute calibration of a soft X-ray spectrograph for X-ray laser research using white beam.
• Characteristics of patients with early systemic sclerosis and severe gastrointestinal tract involvement.
• Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.
• Chemical specificity in short-chain fatty acids and their analogues in increasing osmotic fragility in rat erythrocytes in vitro.
• Comparison of 2 contrast materials with different iodine concentrations in 3-dimensional computed tomography angiography of the hepatic artery at multi-detector-row computed tomography: a randomized study.
• Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus: interleukin 6 (IL-6), IL-8, interferon-alpha, IgG index, and Q-albumin.
• Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance.
• Ecdysone receptor expression in developing and adult mushroom bodies of the ant Camponotus japonicus.
• Effect of antifungal azoles on the heme detoxification system of malarial parasite.
• Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement.
• Genetic mapping of a food preference gene in the silkworm, Bombyx mori, using restriction fragment length polymorphisms (RFLPs).
• Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity.
• Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia.
• Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia.
• Peptides derived from dolicholin, a phaseolin-like protein in country beans (Dolichos lablab), potently stimulate cholecystokinin secretion from enteroendocrine STC-1 cells.
• Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment.
• Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properti
• Pyogenic splenic abscess in an infant with serological evidence of cat scratch disease.
• Rifampicin inhibits the retinal neovascularization in vitro and in vivo.
• Serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure.
• Stereoselective Synthesis of (E)- and (Z)-Fluoroalkenylboronates Using 2-Fluoroalkylideneiodonium Ylides Generated from (2-Fluoro-1-alkenyl)iodonium Salts.
• Stereoselective synthesis of 5-7 membered cyclic ethers by deiodonative ring-enlargement using hypervalent iodine reagents.
• Structure-specific effects of thyroxine analogs on human liver 3 alpha-hydroxysteroid dehydrogenase.
• Surgical management of petroclival chordomas: report of eight cases.
• The relationship between retrieval success and task performance during the recognition of meaningless shapes: an event-related near-infrared spectroscopy study.
• Upper cervical spine movement during intubation: fluoroscopic comparison of the AirWay Scope, McCoy laryngoscope, and Macintosh laryngoscope.
• Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals.
• [Assessment of Biomechanical Characteristic of Denture Supporting Tissue using an Ultrasonic Thickness Gage and a Tactile Sensor.]
• [Changes in Outcome Evaluation before and after Wearing New Complete Dentures.]