Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine.

Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine. Research Abstract Details 

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Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine. Abstract Text:

F Tan,X Feng,Z Fang,M Li,Y Guo,L Jiang,F Tan,X Feng,Z Fang,M Li,Y Guo,L Jiang,F Tan,X Feng,Z Fang,M Li,Y Guo,L Jiang,

Mitochondria are essential cell organelles of eukaryotes. Hence, it is vitally important to develop an automated and reliable method for timely identification of novel mitochondrial proteins. In this study, mitochondrial proteins were encoded by dipeptide composition technology; then, the genetic algorithm-partial least square (GA-PLS) method was used to evaluate the dipeptide composition elements which are more important in recognizing mitochondrial proteins; further, these selected dipeptide composition elements were applied to support vector machine (SVM)-based classifiers to predict the mitochondrial proteins. All the models were trained and validated by the jackknife cross-validation test. The prediction accuracy is 85%, suggesting that it performs reasonably well in predicting the mitochondrial proteins. Our results strongly imply that not all the dipeptide compositions are informative and indispensable for predicting proteins. The source code of MATLAB and the dataset are available on request under liml@scu.edu.cn.

Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine. Publishing Authors By Initials

F Tan,X Feng,Z Fang,M Li,Y Guo,L Jiang,F Tan,X Feng,Z Fang,M Li,Y Guo,L Jiang,F Tan,X Feng,Z Fang,M Li,Y Guo,L Jiang,

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Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Amino acids

VOLUME: 33

Page Numbers: 669-75

Journal Abbreviation: Amino Acids

ISSN: 0939-4451

DAY: 15

MONTH: 08

YEAR: 2007

Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine. Information

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LANGUAGE: eng

NlmUniqueID: 9200312

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Grant and Affiliation Information for Prediction of mitochondrial proteins based on genetic algorithm - partial least squares and support vector machine.

AFFILIATION: College of Chemistry, Sichuan University, Chengdu, China.

Country: Austria

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MEDLINETA: Amino Acids

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