Prediction of Long-Term Renal Transplant Allograft Function From Day 3 Post-transplant Tc-99m MAG3 Scintigraphy.

Prediction of Long-Term Renal Transplant Allograft Function From Day 3 Post-transplant Tc-99m MAG3 Scintigraphy. Research Abstract Details 

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Prediction of Long-Term Renal Transplant Allograft Function From Day 3 Post-transplant Tc-99m MAG3 Scintigraphy. Abstract Text:

Stanley Ngai,Timothy Demetriades,

PURPOSE:: Serum creatinine (sCr) levels of >1.5mg/dL or >130 ummol/L at 1 year after renal transplantation were strongly predictive of long-term allograft survival. A Tc-99m MAG3 study with a Hilson's perfusion index (PI) is routinely performed on day 3 post-transplantation at Princess Alexandra Hospital, Australia. The predictive power of day 3 post-transplantation Hilson's PI for long-term sCr levels; and early sCr levels (at 1 or 3 months) to predict sCr levels at 12 months post-transplantation were studied. MATERIALS AND METHODS:: One hundred eight patients receiving renal transplantation from April 2001 to March 2002 were retrospectively analyzed. sCr levels at 1, 3, and12 months, and 5 years after renal transplantation were recorded and compared with the day 3 post-transplantation Hilson's PI. RESULTS:: Accuracy of 72% to 74%, and 90% sensitivity were recorded between Hilson's PIs and sCr levels up to 12-month post-transplantation. Spearman's correlation shows a significant relationship (R = 0.32-0.39, P = 0.00002-0.003). However, the association seems to have low specificity. A significant relationship was found for early sCr levels (at 1 or 3 months) to predict sCr levels at 12-month post-transplantation, with a Spearman correlation coefficient (R = 0.68-0.85, P < 0.000001). CONCLUSION:: There is a strong relationship between the day 3 Hilson's PIs and serial sCr levels post-transplantation, and between the early sCr levels (1 and 3 months), and the 12 months sCr levels post-transplantation. A composite index integrating these 2 markers to predict long-term renal allograft survival remains to be investigated.

Prediction of Long-Term Renal Transplant Allograft Function From Day 3 Post-transplant Tc-99m MAG3 Scintigraphy. Publishing Authors By Initials

S Ngai,T Demetriades,

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Prediction of Long-Term Renal Transplant Allograft Function From Day 3 Post-transplant Tc-99m MAG3 Scintigraphy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical nuclear medicine

VOLUME: 33

Page Numbers: 102-5

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ISSN: 0363-9762

DAY: 22

MONTH: Feb

YEAR: 2008

Prediction of Long-Term Renal Transplant Allograft Function From Day 3 Post-transplant Tc-99m MAG3 Scintigraphy. Information

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LANGUAGE: eng

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AFFILIATION: From the Department of Radiology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Country: United States

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MEDLINETA: Clin Nucl Med

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