Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia.

Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia. Research Abstract Details 

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Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia. Abstract Text:

K Yamada,H A Neumann,H H Fiebig,R Engelhardt,H Tokita,

In order to estimate its ability to predict the thermochemosensitivity of human cancers, a rapid in vitro assay based on morphological changes in the nucleus was performed on eight different human tumors (four malignant melanomas, two lung tumors, one renal carcinoma, and leukemia K-562). Nude mice, implanted with tumors, supplied the tumor material, with the exception of leukemia. Nimustine, melphalan, mitomycin C, vincristine and vinblastine were tested. Tumor cells developed karyorrhectic changes after incubation for 4 h with each of the aforementioned five drugs. An increase in the karyorrhectic changes was observed with hyperthermia at 43 degrees C. The individual tumors showed different sensitivities to 43 degrees C. Five of the eight tumors were significantly sensitive to 43 degrees C. However, in two thermosensitive tumors no drug enhancement was recognized at 43 degrees C. In four tumors several drugs were synergistically enhanced by hyperthermia at 43 degrees C. This study suggests that this simple method may be of clinical use in predicting response to thermochemotherapy.

Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia. Publishing Authors By Initials

K Yamada,HA Neumann,HH Fiebig,R Engelhardt,H Tokita,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 109

Page Numbers: 250-7

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1988

Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia. Information

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LANGUAGE: eng

NlmUniqueID: 44671

Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: drug effects

Chemical & Substance for Abstract: Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia. Information

Substance Name: Antineoplastic Agents

Registry Number: 0

Grant and Affiliation Information for Predicting the sensitivity of human cancers to combined chemotherapy and hyperthermia.

AFFILIATION: Medizinische Klinik, Albert-Ludwigs-Universität, Freiburg, FRG.

Country: GERMANY, WEST

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MEDLINETA: Recent Results Cancer Res

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