[Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay]

[Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay] Research Abstract Details 

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[Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay] Abstract Text:

Kentaro Matsuura,Yasuhito Tanaka,Kazumi Takagi,Kumiko Hiramatsu,Satomi Kani,Takaaki Gotoh,Yukio Wakimoto,Takashi Joh,Masashi Mizokami,Kentaro Matsuura,Yasuhito Tanaka,Kazumi Takagi,Kumiko Hiramatsu,Satomi Kani,Takaaki Gotoh,Yukio Wakimoto,Takashi Joh,Masashi Mizokami,

The Abbott Real Time HCV assay (lower limit of detection 12 IU/ml) was developed as a highly sensitive HCV RNA quantitative assay using real-time detection PCR(RTD-PCR). We assessed whether the new assay more effectively predicts sustained virological response (SVR) than conventional PCR (PCR) in 38 chronic hepatitis patients infected with HCV genotype 1b and treated with pegylated interferon alpha2b plus ribavirin. Sixteen patients reached SVR, 10 patients relapsed, 9 patients did not respond, 3 patients discontinued treatment. Positive predictive value (PPV) for SVR of undetectable HCV RNA at W4, 8, 12 by RTD-PCR and PCR was (100% vs. 100% at W4), (100% vs. 100% at W8), (83.3% vs. 72.7% at W12). HCV RNA undetectable at W12 had a higher PPV for SVR when measured by RTD-PCR than by conventional PCR.

[Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay] Publishing Authors By Initials

K Matsuura,Y Tanaka,K Takagi,K Hiramatsu,S Kani,T Gotoh,Y Wakimoto,T Joh,M Mizokami,K Matsuura,Y Tanaka,K Takagi,K Hiramatsu,S Kani,T Gotoh,Y Wakimoto,T Joh,M Mizokami,

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[Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Rinsho byori. The Japanese journal of clinical pat

VOLUME: 55

Page Numbers: 983-8

Journal Abbreviation: Rinsho Byori

ISSN: 0047-1860

DAY: 24

MONTH: Nov

YEAR: 2007

[Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay] Information

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LANGUAGE: jpn

NlmUniqueID: 2984781

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Grant and Affiliation Information for [Predicting sustained virological response in chronic hepatitis C patients treated with pegylated interferon and ribavirin using a novel highly sensitive Real-time detection PCR assay]

AFFILIATION: Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya.

Country: Japan

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MEDLINETA: Rinsho Byori

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