Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model.

Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model. Research Abstract Details 

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Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model. Abstract Text:

Ruey-Horng Rau,Yu-Chuan Li,Jen-Kun Cheng,Chien-Chuan Chen,Yuan-Pi Ko,Chun-Jen Huang,

BACKGROUND: Propofol is a common intravenous agent for induction and maintenance of anesthesia. The advantage of propofol is rapid recovery of consciousness when the continuous infusion is stopped. Additionally, it has antiemetic effect of reducing postoperative nausea and vomiting. On the other hand, rapid infusion of propofol is painful and may cause hypotension. In this study, we aimed to develop a logistic regression model to accurately predict blood pressure change caused by rapid infusion of propofol. METHODS: Seventeen variables (including demographic data, past medical history, laboratory data, and blood pressure before induction) were assessed in 200 patients who received propofol for induction of anesthesia for routine surgery. A logistic regression model was derived using these values as independent variables to predict whether a patient would suffer a significant blood pressure change (> 30% decrease from baseline). Sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated to evaluate the performance of our prediction model. RESULTS: A cut-off value of 0.17 in the logistic regression model predicted decreased blood pressure with 90.0% sensitivity and, 67.3% specificity. The area under the receiver operating characteristic curve was 0.855. CONCLUSIONS: Our prediction model predicts propofol-induced hypotension with acceptable accuracy. Because of the straightforward mathematic formula used, our model can be integrated effortlessly into a hospital information system, providing a reliable and useful decision support for clinical anesthesia staff.

Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model. Publishing Authors By Initials

RH Rau,YC Li,JK Cheng,CC Chen,YP Ko,CJ Huang,

For similar organic chemicals: phenols: propofol research abstracts see: organic chemicals: phenols: propofol research

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Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta anaesthesiologica Taiwanica : official journa

VOLUME: 42

Page Numbers: 81-6

Journal Abbreviation:

ISSN: 1875-4597

DAY: 7

MONTH: Jun

YEAR: 2004

Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model. Information

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LANGUAGE: eng

NlmUniqueID: 101214918

Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model. Keywords Mesh Terms:

KEYWORDS: Propofol

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model. Information

Substance Name: Propofol

Registry Number: 2078-54-8

Grant and Affiliation Information for Predicting blood pressure change caused by rapid injection of propofol during anesthesia induction with a logistic regression model.

AFFILIATION: Department ofAnesthesiology, Mackay Memorial Hospital, Taipei, Taiwan, R.O.C. Johnson@ms1.mmh.org.tw

Country: China (Republic: 1949- )

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MEDLINETA: Acta Anaesthesiol Taiwan

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