Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B.

Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B. Research Abstract Details 

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Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B. Abstract Text:

He-Jun Yuan,Danny Ka-Ho Wong,Joke Doutreloigne,Erwin Sablon,Ching-Lung Lai,Man-Fung Yuen,

OBJECTIVE: To determine the prevalence of precore and core promoter (CP) mutations before, at and after HBeAg seroclearance in Chinese patients. METHODS: Precore and CP mutations were determined in 93 patients with chronic hepatitis B 12-24 months before, at and 12 months after the time of HBeAg seroclearance. RESULTS: No significant changes were found in the prevalence of precore or CP mutations before, at and after HBeAg seroclearance. Seven patients (7.8%) had HBeAg seroreversion within 1 year of HBeAg seroclearance. There was no significant difference in the prevalence of precore and CP mutations between patients with and without HBeAg seroreversion. 68.3% and 48.7% of patients harbored the same precore and CP genotypes throughout. 32.0% patients with precore mutations and 8.9% patients with CP mutations before HBeAg seroclearance had reversion to wild type within 1 year of HBeAg seroclearance. Patients with genotype C patients had a higher prevalence of CP mutations before HBeAg seroclearance compared with patients with genotype B (82.4% vs. 44%, P=0.001). CONCLUSIONS: Precore and CP mutations existed in a substantial proportion of Chinese patients before HBeAg seroclearance. The replication of precore and, to a lesser extent, CP mutants could be suppressed around the time of HBeAg seroclearance.

Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B. Publishing Authors By Initials

HJ Yuan,D Ka-Ho Wong,J Doutreloigne,E Sablon,CL Lai,MF Yuen,

For similar proteins: protein precursors research abstracts see: proteins: protein precursors research

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Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of infection

VOLUME: 54

Page Numbers: 497-503

Journal Abbreviation: J. Infect.

ISSN: 1532-2742

DAY: 25

MONTH: 09

YEAR: 2006

Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B. Information

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LANGUAGE: eng

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Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B. Keywords Mesh Terms:

KEYWORDS: Protein Precursors

MESH TERMS: genetics

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Substance Name: Protein Precursors

Registry Number: 0

Grant and Affiliation Information for Precore and core promoter mutations at the time of HBeAg seroclearance in Chinese patients with chronic hepatitis B.

AFFILIATION: Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR China.

Country: England

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MEDLINETA: J Infect

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