Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures.

Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures. Research Abstract Details 

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Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures. Abstract Text:

J D Rolston,D A Wagenaar,S M Potter,J D Rolston,D A Wagenaar,S M Potter,

Recurring patterns of neural activity, a potential substrate of both information transfer and transformation in cortical networks, have been observed in the intact brain and in brain slices. Do these patterns require the inherent cortical microcircuitry of such preparations or are they a general property of self-organizing neuronal networks? In networks of dissociated cortical neurons from rats--which lack evidence of the intact brain's intrinsic cortical architecture--we have observed a robust set of spontaneously repeating spatiotemporal patterns of neural activity, using a template-matching algorithm that has been successful both in vivo and in brain slices. The observed patterns in cultured monolayer networks are stable over minutes of extracellular recording, occur throughout the culture's development, and are temporally precise within milliseconds. The identification of these patterns in dissociated cultures opens a powerful methodological avenue for the study of such patterns, and their persistence despite the topological and morphological rearrangements of cellular dissociation is further evidence that precisely timed patterns are a universal emergent feature of self-organizing neuronal networks.

Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures. Publishing Authors By Initials

JD Rolston,DA Wagenaar,SM Potter,JD Rolston,DA Wagenaar,SM Potter,

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Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuroscience

VOLUME: 148

Page Numbers: 294-303

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 5

MONTH: 07

YEAR: 2007

Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures. Information

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LANGUAGE: eng

NlmUniqueID: 7605074

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Grant and Affiliation Information for Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures.

AFFILIATION: Laboratory for Neuroengineering, Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332-0535, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS38628

ACRONYM: NS

MEDLINETA: Neuroscience

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