Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin.

Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin. Research Abstract Details 

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Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin. Abstract Text:

Crossed immunoelectrophoresis was used to study precipitating antibodies against Neisseria meningitidis in sera from 214 normal persons and in human gammaglobulin. A polyspecific meningococcal antigen preparation and a corresponding rabbit antiserum constituted the reference system. All the sera contained one to five precipitins against N. meningitidis which could be identified and quantified by means of the reference system. The precipitin score, which expresses the number and titre of precipitins in each serum, increased with age. More than 25 precipitins were found in the gammaglobulin preparation, including antibodies against the groupspecific polysaccharides A, B and C. Absorption of three of the five normally occurring precipitins (nos. 4, 19, 22) with antigens from various bacteria showed that precipitins nos. 4 and 19 could be completely absorbed by antigens from other Neisseria species, but not by antigens from other genera. This indicates that these two precipitins may have been induced by non-pathogenic Neisseria species or by meningococci. The finding of protective antibodies in gammaglobulin might indicate the possibility of its use in prophylaxis or therapy meningococcal infections.

Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin. Publishing Authors By Initials

For similar proteins: blood proteins: immunoproteins: immunoglobulins: gamma-globulins research abstracts see: proteins: blood proteins: immunoproteins: immunoglobulins: gamma-globulins research

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Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta pathologica et microbiologica Scandinavica. S

VOLUME: 86C

Page Numbers: 123-9

Journal Abbreviation:

ISSN: 0304-1328

DAY: 26

MONTH: Jun

YEAR: 1978

Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin. Information

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LANGUAGE: eng

NlmUniqueID: 7508469

Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin. Keywords Mesh Terms:

KEYWORDS: gamma-Globulins

MESH TERMS: immunology

Chemical & Substance for Abstract: Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin. Information

Substance Name: gamma-Globulins

Registry Number: 0

Grant and Affiliation Information for Precipitating antibodies against Neisseria meningitidis in normal sera and their possible origin.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Scand [C

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