Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study.

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Abstract Text:

Kullervo Hynynen,Nathan McDannold,Greg Clement,Ferenc A Jolesz,Eyal Zadicario,Ron Killiany,Tara Moore,Douglas Rosen,

MRI-guided and monitored focused ultrasound thermal surgery of brain through intact skull was tested in three rhesus monkeys. The aim of this study was to determine the amount of skull heating in an animal model with a head shape similar to that of a human. The ultrasound beam was generated by a 512 channel phased array system (Exablate 3000, InSightec, Haifa, Israel) that was integrated within a 1.5-T MR-scanner. The skin was pre-cooled by degassed temperature controlled water circulating between the array surface and the skin. Skull surface temperature was measured with invasive thermocouple probes. The results showed that by applying surface cooling the skin and skull surface can be protected, and that the brain surface temperature becomes the limiting factor. The MRI thermometry was shown to be useful in detecting the tissue temperature distribution next to the bone, and it should be used to monitor the brain surface temperature. The acoustic intensity values during the 20 s sonications were adequate for thermal ablation in the human brain provided that surface cooling is used.

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Publishing Authors By Initials

K Hynynen,N McDannold,G Clement,FA Jolesz,E Zadicario,R Killiany,T Moore,D Rosen,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of radiology

VOLUME: 59

Page Numbers: 149-56

Journal Abbreviation:

ISSN: 0720-048X

DAY: 23

MONTH: 05

YEAR: 2006

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8106411

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study.

AFFILIATION: Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. kullervo@bwh.harvard.edu

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Radiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study Related Publications

• A 29-year-old man with subcutaneous emphysema of the neck following blunt trauma.
• A web portal that enables collaborative use of advanced medical image processing and informatics tools through the Biomedical Informatics Research Network (BIRN).
• Acute rejection in HCV-infected liver transplant recipients: The great conundrum.
• Are stem cells drugs? The regulation of stem cell research and development.
• ArsD residues Cys12, Cys13, and Cys18 form an As(III)-binding site required for arsenic metallochaperone activity.
• BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.
• Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair.
• Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade.
• Diagnosis and management of laryngopharyngeal reflux disease.
• Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.
• Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family.
• Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues.
• Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases.
• Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8.
• Hetereogeneity in skeletal response to full-length parathyroid hormone in the treatment of osteoporosis.
• I(Kr) contributes to the altered ventricular repolarization that determines long-term cardiac memory.
• Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum.
• Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1 alpha upon differentiation of an eosinophilic HL-60 cell line.
• Integration is as essential as balance.
• Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers.
• Linking cost sharing to value: an unrivaled yet unrealized public health opportunity.
• Long-term cardiac memory in canine heart is associated with the evolution of a transmural repolarization gradient.
• Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence.
• Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics.
• Measuring the activities of the Sulfs: two novel heparin/heparan sulfate endosulfatases.
• Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.
• Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study.
• Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating.
• Sulfated L-selectin ligands as a therapeutic target in chronic inflammation.
• The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2.