pRb and condensin--local control of global chromosome structure.

pRb and condensin--local control of global chromosome structure. Research Abstract Details 

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pRb and condensin--local control of global chromosome structure. Abstract Text:

Rb mutants exhibit aneuploidy and aberrant chromosome structure during mitosis. In this issue of Genes & Development, a new paper from Longworth and colleagues (1011-1024) describes both physical and functional interactions between Drosophila Rbf1 and the dCAP-D3 subunit of condensin II. This work directly implicates the Rb family proteins in mitotic chromosome condensation and suggests that a failure in targeting condensin II to chromatin underlies the aneuploidy in rbf1 mutants.

pRb and condensin--local control of global chromosome structure. Publishing Authors By Initials

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pRb and condensin--local control of global chromosome structure. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genes & development

VOLUME: 22

Page Numbers: 964-9

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 15

MONTH: Apr

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 8711660

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AFFILIATION: Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Country: United States

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MEDLINETA: Genes Dev

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