Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits.

Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits. Research Abstract Details 

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Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits. Abstract Text:

Narentuoya Bao,Shinya Minatoguchi,Hiroyuki Kobayashi,Shinji Yasuda,Itta Kawamura,Masamitsu Iwasa,Takahiko Yamaki,Syohei Sumi,Yu Misao,Masazumi Arai,Kazuhiko Nishigaki,Genzou Takemura,Takako Fujiwara,Hisayoshi Fujiwara,Narentuoya Bao,Shinya Minatoguchi,Hiroyuki Kobayashi,Shinji Yasuda,Itta Kawamura,Masamitsu Iwasa,Takahiko Yamaki,Syohei Sumi,Yu Misao,Masazumi Arai,Kazuhiko Nishigaki,Genzou Takemura,Takako Fujiwara,Hisayoshi Fujiwara,

BACKGROUND: Statins reportedly protect against myocardial infarction, but the precise mechanism is unclear. METHODS AND RESULTS: Rabbits underwent 30 min of coronary occlusion followed by 48 h of reperfusion. Pravastatin (1 or 5 mg/kg) or saline was intravenously administered 10 min before ischemia. Pravastatin (5 mg/kg) was also administered 10 min before reperfusion. N(omega)-nitro-L-arginine methylester (L-NAME, 10 mg/kg), chelerythrine (5 mg/kg) or 5-hydroxydecanoic acid sodium salt (5-HD, 5 mg/kg) was intravenously administered 10 min before pravastatin injection. The infarct size was determined. The myocardial interstitial levels of 2,5-dihydroxybenzoic acid (DHBA) and nitrogen oxide (NOx), and the intensity of myocardial dihydroethidium staining were measured. Pre-ischemic treatment with pravastatin reduced the infarct size (34+/-5% and 24+/-4%, 1 and 5 mg/kg, respectively), but not pre-reperfusion treatment (42.1+/-3.7%), compared with the control (45+/-3%). This effect was blocked by L-NAME (42.6+/-4%), chelerythrine (50.9+/-3%) and 5-HD (52.7+/-2%). Pre-ischemic treatment with pravastatin increased myocardial NOx levels, and attenuated both the 2,5-DHBA level and the intensity of dihydroethidium staining during reperfusion. Chelerythrine abolished the increase in NOx levels by pravastatin. CONCLUSION: Pre-ischemic treatment with pravastatin reduces the myocardial infarct size via protein kinase C-dependent nitric oxide production, decreasing hydroxyl radicals and superoxide, and opening the mitochondrial adenosine triphosphate-sensitive potassium channels.

Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits. Publishing Authors By Initials

N Bao,S Minatoguchi,H Kobayashi,S Yasuda,I Kawamura,M Iwasa,T Yamaki,S Sumi,Y Misao,M Arai,K Nishigaki,G Takemura,T Fujiwara,H Fujiwara,N Bao,S Minatoguchi,H Kobayashi,S Yasuda,I Kawamura,M Iwasa,T Yamaki,S Sumi,Y Misao,M Arai,K Nishigaki,G Takemura,T Fujiwara,H Fujiwara,

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Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Circulation journal : official journal of the Japa

VOLUME: 71

Page Numbers: 1622-8

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 26

MONTH: Oct

YEAR: 2007

Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits. Information

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LANGUAGE: eng

NlmUniqueID: 101137683

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AFFILIATION: Second Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan.

Country: Japan

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MEDLINETA: Circ J

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