Practical considerations in establishing reliable and sensitive neurobehavioral test methods.

Practical considerations in establishing reliable and sensitive neurobehavioral test methods. Research Abstract Details 

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Practical considerations in establishing reliable and sensitive neurobehavioral test methods. Abstract Text:

The use of animal models in the safety assessment of compounds requires that the methods employed be established as reliable, sensitive and valid indicators of toxicity. Neurobehavioral toxicology is in a unique position due to recent efforts in this area prior to incorporation into routine screening systems. Aspects of study design and general implications of results are discussed from the Collaborative Behavioral Teratology Study, a large-scale effort specifically undertaken to evaluate the reliability and sensitivity of a standardized behavioral teratology test protocol. In control animals in any given measure used, comparable trial-, day- or age-related patterns were obtained in all 6 participating laboratories. In addition, prenatal treatment-related alterations observed were consistent within and across laboratories in both the amphetamine and methylmercury studies. For the majority of endpoints monitored, coefficients of detection calculated from vehicle control data estimated that a 5-25% change in behavior in treated groups could be detected statistically. Thus, with use of an adequate design and sample size within a standardized protocol, it is possible to identify the presence or absence of behavioral change with some confidence.

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Practical considerations in establishing reliable and sensitive neurobehavioral test methods. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zentralblatt für Bakteriologie, Mikrobiologie und

VOLUME: 185

Page Numbers: 4-9

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ISSN: 0932-6073

DAY: 26

MONTH: Oct

YEAR: 1987

Practical considerations in establishing reliable and sensitive neurobehavioral test methods. Information

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LANGUAGE: eng

NlmUniqueID: 8606774

Practical considerations in establishing reliable and sensitive neurobehavioral test methods. Keywords Mesh Terms:

KEYWORDS: Nervous System

MESH TERMS: drug effects

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Grant and Affiliation Information for Practical considerations in establishing reliable and sensitive neurobehavioral test methods.

AFFILIATION: Lilly Research Laboratories, Division of Eli Lilly Co., Greenfield, IN 46140.

Country: GERMANY, WEST

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MEDLINETA: Zentralbl Bakteriol Mikrobiol

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