Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia.

Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. Research Abstract Details 

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Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. Abstract Text:

John Gardiner,Deborah Barton,Jan Marc,Robyn Overall,John Gardiner,Deborah Barton,Jan Marc,Robyn Overall,

Familial dysautonomia (FD), a disease of the autonomic and sensory nervous systems, involves mutations in the protein IkappaB kinase complex-associated protein, which is a component of the human Elongator acetylase complex. We suggest a hypothesis in which defects in tubulin acetylation and impairment of microtubule-based protein trafficking may be an underlying cause of FD. In addition, an Arabidopsis homolog of the Elongator subunit ELP3 has been found to bind to the alphabeta-tubulin heterodimer, suggesting that alpha-tubulin may be a cytoplasmic target of Elongator acetylase activity. Studies of synergistic double mutants in yeast indicate a novel role for Elongator in cytoskeletal dynamics, although this is probably because of an effect on actin rather than microtubules. Finally, we suggest that tubulin deacetylase inhibitors may prove useful in the treatment of FD.

Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. Publishing Authors By Initials

J Gardiner,D Barton,J Marc,R Overall,J Gardiner,D Barton,J Marc,R Overall,

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Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Traffic (Copenhagen, Denmark)

VOLUME: 8

Page Numbers: 1145-9

Journal Abbreviation: Traffic

ISSN: 1398-9219

DAY: 1

MONTH: 07

YEAR: 2007

Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. Information

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LANGUAGE: eng

NlmUniqueID: 100939340

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AFFILIATION: School of Biological Sciences, Macleay Building (A12), Science Road, The University of Sydney, Camperdown 2006, Australia. jgardiner@usyd.edu.au

Country: Denmark

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MEDLINETA: Traffic

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