Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion development in F344 rat medium-term bioassay.

Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion development in F344 rat medium-term bioassay. Research Abstract Details 

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Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion development in F344 rat medium-term bioassay. Abstract Text:

d-Allose, the C-3 epimer of d-glucose, is a monosaccharide present in minute quantities in nature and a rare sugar. The effects of d-allose on diethyl nitrosamine (DEN)-induced hepatocarcinogenesis were examined in male F344 rats by a rat medium-term bioassay based on the two-step model of hepatocarcinogenesis (experiment 1). In addition, a DNA microarray analysis was employed to clarify possible mechanisms of action of d-allose (experiment 2). The antioxidation potential of d-allose solution itself or of serum in rats treated with d-allose was also examined directly by measuring Cu(+)-reducing antioxidation power (experiment 3). Furthermore, to investigate the effects of d-allose in vivo under conditions of oxidative stress, it was administered with a choline-deficient, l-amino acid-defined diet (CDAA) in the medium-term liver carcinogenesis bioassay (experiment 4). Experiment 1 demonstrated no effects of d-allose on the development of glutathione S-transferase placental form (GST-P) positive foci in the liver. From DNA microarray analysis, several mRNA markers were found to be altered with functions related to apoptosis and cell proliferation (experiment 2), although d-allose itself and serum in vivo exhibited no antioxidation power directly (experiment 3). When d-allose was administered with the CDAA diet, decreases in the area and number of GST-P positive foci were noted with P values of 0.158 for area (%) and 0.061 for number (/cm(2)) (experiment 4). These results suggest the potential inhibitory effect of d-allose on liver carcinogenesis, particularly under oxidative stress conditions.

Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion development in F344 rat medium-term bioassay. Publishing Authors By Initials

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Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion development in F344 rat medium-term bioassay. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of bioscience and bioengineering

VOLUME: 105

Page Numbers: 545-53

Journal Abbreviation: J. Biosci. Bioeng.

ISSN: 1389-1723

DAY: 18

MONTH: May

YEAR: 2008

Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion development in F344 rat medium-term bioassay. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Potential inhibitory effects of d-allose, a rare sugar, on liver preneoplastic lesion development in F344 rat medium-term bioassay.

AFFILIATION: Onco-Pathology, Department of Pathology and Host-Defence, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.

Country: Japan

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MEDLINETA: J Biosci Bioeng

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