Potential immunopathogenic role of the mucosa-bone marrow axis in IgA nephropathy: insights from animal models.

Potential immunopathogenic role of the mucosa-bone marrow axis in IgA nephropathy: insights from animal models. Research Abstract Details 

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Potential immunopathogenic role of the mucosa-bone marrow axis in IgA nephropathy: insights from animal models. Abstract Text:

Yusuke Suzuki,Yasuhiko Tomino,Yusuke Suzuki,Yasuhiko Tomino,

Impaired immune regulation along the mucosa-bone marrow axis has been postulated to play an important role in the pathogenesis of IgA nephropathy. Animal models have allowed us to study such changes in detail. Accumulating evidence from a number of animal models suggest that there is dysregulation of innate and cellular immunity in IgA nephropathy, resulting in changes to the mucosal immune system. These changes appear to be linked closely to a disruption of mucosal tolerance, resulting in the abnormal priming and dissemination of cells to sites such as the bone marrow where they are responsible for the synthesis of nephritogenic IgA. These findings suggest that future treatment strategies should focus on manipulating the priming and dissemination of these memory cells to prevent the appearance of nephritogenic IgA in the systemic compartment.

Potential immunopathogenic role of the mucosa-bone marrow axis in IgA nephropathy: insights from animal models. Publishing Authors By Initials

Y Suzuki,Y Tomino,Y Suzuki,Y Tomino,

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Potential immunopathogenic role of the mucosa-bone marrow axis in IgA nephropathy: insights from animal models. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Seminars in nephrology

VOLUME: 28

Page Numbers: 66-77

Journal Abbreviation: Semin. Nephrol.

ISSN: 0270-9295

DAY: 28

MONTH: Jan

YEAR: 2008

Potential immunopathogenic role of the mucosa-bone marrow axis in IgA nephropathy: insights from animal models. Information

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LANGUAGE: eng

NlmUniqueID: 8110298

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Grant and Affiliation Information for Potential immunopathogenic role of the mucosa-bone marrow axis in IgA nephropathy: insights from animal models.

AFFILIATION: Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Country: United States

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MEDLINETA: Semin Nephrol

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