Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection.

Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. Research Abstract Details 

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Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. Abstract Text:

Vance G Fowler,Charlotte L Nelson,Lauren M McIntyre,Barry N Kreiswirth,Alastair Monk,Gordon L Archer,Jerome Federspiel,Steven Naidich,Brian Remortel,Thomas Rude,Pamela Brown,L Barth Reller,G Ralph Corey,Steven R Gill,

BACKGROUND: The impact of bacterial clonality on infections caused by Staphylococcus aureus is unclear. METHODS: Three hundred seventy-nine S. aureus isolates (125 methicillin-resistant S. aureus [MRSA] and 254 methicillin-susceptible S. aureus [MSSA]) were genotyped by spa typing and multilocus sequence typing. For MRSA isolates, the staphylococcal chromosomal cassette mec (SCCmec) element was also typed. Three clinical categories were identified: nasal carriage only (n=118), uncomplicated infection (n=104), and bacteremia with hematogenous complications (n=157). RESULTS: By use of eBURST, 18 clonal complexes (CCs) were found in 371 isolates. Eight CCs accounted for 89% of isolates and occurred in all clinical categories. CC5 (P=.0025) and CC30 (P=.0308) exhibited a significant trend toward more frequent hematogenous complications. Isolates within spa types 2 and 16 showed the same significant trend and grouped within CC5 and CC30, respectively. SCCmec II isolates also showed the same significant trend compared with SCCmec IV; 96% were CC5 or CC30. CONCLUSIONS: Although most S. aureus genotypes exhibited the capacity to cause invasive disease, strains within CC5 and CC30 exhibited a significant trend toward increasing levels of hematogenous complications. Isolates within these CCs were also implicated by use of spa and SCCmec typing. The genetic determinants underlying these findings remain to be demonstrated.

Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. Publishing Authors By Initials

VG Fowler,CL Nelson,LM McIntyre,BN Kreiswirth,A Monk,GL Archer,J Federspiel,S Naidich,B Remortel,T Rude,P Brown,LB Reller,GR Corey,SR Gill,

For similar bacteria: gram-positive bacteria: gram-positive cocci: staphylococcaceae: staphylococcus: staphylococcus aureus research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: staphylococcaceae: staphylococcus: staphylococcus aureus research

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Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of infectious diseases

VOLUME: 196

Page Numbers: 738-47

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 20

MONTH: 07

YEAR: 2007

Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. Keywords Mesh Terms:

KEYWORDS: Staphylococcus aureus

MESH TERMS: genetics

Chemical & Substance for Abstract: Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. Information

Substance Name: Anti-Bacterial Agents

Registry Number: 0

Grant and Affiliation Information for Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection.

AFFILIATION: Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. vance.fowler@duke.edu

Country: United States

AGENCY: United States NIAID

GRANT: R01AI059111

ACRONYM: AI

MEDLINETA: J Infect Dis

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