Potential adverse effects of proton pump inhibitors.

Potential adverse effects of proton pump inhibitors. Research Abstract Details 

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Potential adverse effects of proton pump inhibitors. Abstract Text:

Proton pump inhibitors (PPIs) have revolutionized the management of gastroesophageal reflux disease and peptic ulcer disease over the past two decades. Among the most commonly prescribed agents worldwide, PPIs' overall safety profile is unquestionable. However, emerging evidence indicates that PPI therapy, particularly with long-term and/or high-dose administration, is associated with several potential adverse effects, including enteric infections (eg, Clostridium difficile), community-acquired pneumonia, and hip fracture, all of which have received much attention recently. We review the current data on these and other potential consequences of PPI therapy. More judicious use of PPIs (eg, administering them in no more than the minimum effective dose to older adult patients) may help to further limit the impact of some of these possible adverse effects.

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Potential adverse effects of proton pump inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current gastroenterology reports

VOLUME: 10

Page Numbers: 208-14

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ISSN: 1534-312X

DAY: 15

MONTH: Jun

YEAR: 2008

Potential adverse effects of proton pump inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 100888896

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Grant and Affiliation Information for Potential adverse effects of proton pump inhibitors.

AFFILIATION: Division of Gastroenterology, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street, Suite 1400, Chicago, IL 60611, USA.

Country: United States

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MEDLINETA: Curr Gastroenterol Rep

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