Potent, selective MCH-1 receptor antagonists.

Potent, selective MCH-1 receptor antagonists. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Potent, selective MCH-1 receptor antagonists. Abstract Text:

Shawn D Erickson,Bruce Banner,Steven Berthel,Karin Conde-Knape,Fiorenza Falcioni,Irina Hakimi,Bernard Hennessy,Robert F Kester,Kyungjin Kim,Chun Ma,Warren McComas,Francis Mennona,Steven Mischke,Lucy Orzechowski,Yimin Qian,Hamid Salari,John Tengi,Kshitij Thakkar,Rebecca Taub,Jefferson W Tilley,Hong Wang,

This paper describes the lead optimization of a new series of potent, selective, orally bioavailable, brain-penetrant MCH-1 receptor antagonists. A major focus of the work was to achieve a selectivity profile appropriate for in vivo efficacy studies and safety.

Potent, selective MCH-1 receptor antagonists. Publishing Authors By Initials

SD Erickson,B Banner,S Berthel,K Conde-Knape,F Falcioni,I Hakimi,B Hennessy,RF Kester,K Kim,C Ma,W McComas,F Mennona,S Mischke,L Orzechowski,Y Qian,H Salari,J Tengi,K Thakkar,R Taub,JW Tilley,H Wang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Potent, selective MCH-1 receptor antagonists. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 1402-6

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 8

MONTH: 01

YEAR: 2008

Potent, selective MCH-1 receptor antagonists. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Potent, selective MCH-1 receptor antagonists. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Potent, selective MCH-1 receptor antagonists. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Potent, selective MCH-1 receptor antagonists.

AFFILIATION: Discovery Chemistry, Hoffmann-La Roche, Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Potent, selective MCH-1 receptor antagonists Related Publications

• A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
• Effects of phytoestrogen genistein on delayed after depolarization and triggered activity induced by ouabain in guinea pig papillary muscles.
• Occupational health in China.
• Research on expression of telomerase in human odontogenic lesions.
• Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signaling.
• [A gene analysis of the low density lipoprotein receptor in Chinese with homozygous familial hyperchol-esterolemia]
• [A novel rat aplastic anemia model induced by 5-fluorouracil combined with busulfan]
• [A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs]
• [An experimental study on the bone repairing ability of recombinant human bone morphogenetic protein-2-coral composited artificial bone]
• [Analysis of EEG based on the complexity measure]
• [Apoptosis of bone marrow cells aplastic anemia patients treated with cyclosporin A]
• [Carrier detection and prenatal diagnosis for hemophilia A]
• [Changes of the expression of integrin alpha6beta1 and the activity of focal adhesion kinase in the liver sinusoidal endothelial cell in experimental fibrotic rats]
• [Clinical analysis of 22 patients with primary biliary cirrhosis]
• [Clinical significance of hemostatic molecular markers in acute leukemia]
• [Effects of phenytoin on structural aberration of human sperm chromosomes in vitro]
• [Expression and purification of human papillomavirus type16 L1 protein in a prokaryotic expression system]
• [Extension of cardiac monitoring function by used of ordinary ECG machine]
• [Histopathological features of 27 cases of primary biliary cirrhosis]
• [Multiagent system for individual artificial hip joint]
• [Neomycin inhibits nicotinic receptor-mediated response in pheochromocytoma (PC12) cells]
• [No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese]
• [PCR cloning of 3'-terminal repeat fragments of Clostridium difficile toxin A and toxin B gene]
• [Preliminary study of prevention from restenosis of hepatic venous in stents by gene transfer of phVEGF165]
• [Prostaglandin inhibitor indomethacin inhibits afferent activities of Adelta and C units in the saphenous nerve of diabetic hyperalgesic rats]
• [Research and development on microwave sterilization]
• [Role of recombinant human bone morphogenetic protein 2/collagen as an onlay bone graft on adult rat calvarial bone]
• [Study of telomerase activity and its related genes expression in leukemia cells]
• [Thrombopoietic effect of recombinant human thrombopoietin gene transferred to mice mediated by electric pulse on normal and experimental thrombocytopenia mice]
• [Thymectomy for late-onset myasthenia gravis in the elderly (with report of 23 cases)]