Potent Anticoagulants are Associated with a Higher All-Cause Mortality Rate After Hip and Knee Arthroplasty.

Potent Anticoagulants are Associated with a Higher All-Cause Mortality Rate After Hip and Knee Arthroplasty. Research Abstract Details 

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Potent Anticoagulants are Associated with a Higher All-Cause Mortality Rate After Hip and Knee Arthroplasty. Abstract Text:

Nigel E Sharrock,Alejandro Gonzalez Della Valle,George Go,Stephen Lyman,Eduardo A Salvati,Nigel E Sharrock,Alejandro Gonzalez Della Valle,George Go,Stephen Lyman,Eduardo A Salvati,

Anticoagulation for thromboprophylaxis after THA and TKA has not been confirmed to diminish all-cause mortality. We determined whether the incidence of all-cause mortality and pulmonary embolism in patients undergoing total joint arthroplasty differs with currently used thromboprophylaxis protocols. We reviewed articles published from 1998 to 2007 that included 6-week or 3-month incidence of all-cause mortality and symptomatic, nonfatal pulmonary embolism. Twenty studies included reported 15,839 patients receiving low-molecular-weight heparin, ximelagatran, fondaparinux, or rivaroxaban (Group A); 7193 receiving regional anesthesia, pneumatic compression, and aspirin (Group B); and 5006 receiving warfarin (Group C). All-cause mortality was higher in Group A than in Group B (0.41% versus 0.19%) and the incidence of clinical nonfatal pulmonary embolus was higher in Group A than in Group B (0.60% versus 0.35%). The incidences of all-cause mortality and nonfatal pulmonary embolism in Group C were similar to those in Group A (0.4 and 0.52, respectively). Clinical pulmonary embolus occurs despite the use of anticoagulants. Group A anticoagulants were associated with the highest all-cause mortality of the three modalities studied. Level of Evidence: Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

Potent Anticoagulants are Associated with a Higher All-Cause Mortality Rate After Hip and Knee Arthroplasty. Publishing Authors By Initials

NE Sharrock,A Gonzalez Della Valle,G Go,S Lyman,EA Salvati,NE Sharrock,A Gonzalez Della Valle,G Go,S Lyman,EA Salvati,

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Potent Anticoagulants are Associated with a Higher All-Cause Mortality Rate After Hip and Knee Arthroplasty. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical orthopaedics and related research

VOLUME: 466

Page Numbers: 714-21

Journal Abbreviation: Clin. Orthop. Relat. Res.

ISSN: 0009-921X

DAY: 10

MONTH: 02

YEAR: 2008

Potent Anticoagulants are Associated with a Higher All-Cause Mortality Rate After Hip and Knee Arthroplasty. Information

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LANGUAGE: eng

NlmUniqueID: 75674

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AFFILIATION: Department of Anesthesiology, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA, sharrockn@hss.edu.

Country: United States

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MEDLINETA: Clin Orthop Relat Res

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