Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits.

Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. Research Abstract Details 

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Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. Abstract Text:

Mark P Mooney,H Wolfgang Losken,Amr M Moursi,Jocelyn M Shand,Gregory M Cooper,Chris Curry,Lillian Ho,Anne M Burrows,Eric J Stelnicki,Joseph E Losee,Lynne A Opperman,Michael I Siegel,

Postoperative resynostosis and secondary craniofacial growth abnormalities are common sequelae after craniofacial surgery. It has been suggested that an overexpression of transforming growth factor-beta2 (Tgf-beta2) may be related to craniosynostosis and contribute to postoperative resynostosis. Interference with Tgf-beta2 function using neutralizing antibodies may inhibit resynostosis and improve postoperative craniofacial growth; the present study was designed to test this hypothesis. Twenty-nine New Zealand white rabbits with bilateral coronal suture synostosis were used: 1) suturectomy controls (n=9); 2) suturectomy with nonspecific, control IgG antibody (n=9); and 3) suturectomy with anti-Tgf-beta2 antibody (n=11). At 10 days of age, a 3 mm x 15-mm coronal suturectomy was performed. The sites in groups 2 and 3 were immediately filled with 0.1 cc of a slow resorbing collagen gel mixed with either IgG (100 microg/suture) or anti-Tgf-beta2 (100 microg/suture). Three-dimensional computed tomography scan reconstructions of the skulls and cephalographs were obtained at 10, 25, 42, and 84 days of age. Computed tomography scan data revealed patent suturectomy sites and significantly (P<0.05) greater intracranial volumes by 84 days of age in rabbits treated with anti-Tgf-beta2 compared with controls. Cephalometric analysis revealed significant (P<0.05) differences in craniofacial, cranial vault, and cranial base growth by 84 days of age in rabbits treated with anti-Tgf-beta2 compared with controls. These data support the initial hypothesis that interference with Tgf-beta2 function inhibited postoperative resynostosis and improved cranial vault growth in this rabbit model. Thus, this biologically based therapy may be a potential surgical adjunct in the treatment of infants with craniosynostosis.

Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. Publishing Authors By Initials

MP Mooney,HW Losken,AM Moursi,JM Shand,GM Cooper,C Curry,L Ho,AM Burrows,EJ Stelnicki,JE Losee,LA Opperman,MI Siegel,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta2 research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta2 research

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Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of craniofacial surgery

VOLUME: 18

Page Numbers: 336-46; discussion 347-9

Journal Abbreviation:

ISSN: 1049-2275

DAY: 3

MONTH: Mar

YEAR: 2007

Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9010410

Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta2

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits. Information

Substance Name: Transforming Growth Factor beta2

Registry Number: 0

Grant and Affiliation Information for Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits.

AFFILIATION: Department of Oral Biology, Cleft Palate-Craniofacial Center, University of Pittsburgh, and Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. mpm4@pitt.edu

Country: United States

AGENCY: United States NIDCR

GRANT: DE13078

ACRONYM: DE

MEDLINETA: J Craniofac Surg

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