Postoperative adjuvant chemotherapy improves survival after surgical resection for pancreatic carcinoma.

Postoperative adjuvant chemotherapy improves survival after surgical resection for pancreatic carcinoma. Research Abstract Details 

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Postoperative adjuvant chemotherapy improves survival after surgical resection for pancreatic carcinoma. Abstract Text:

Yoshiaki Murakami,Kenichiro Uemura,Takeshi Sudo,Yasuo Hayashidani,Yasushi Hashimoto,Hiroki Ohge,Taijiro Sueda,

Pancreatic carcinoma is one of the most aggressive types of gastrointestinal malignancy, and its prognosis remains extremely dismal. The aim of this study was to identify useful prognostic factors for patients undergoing surgical resection for pancreatic carcinoma. Medical records of 89 patients with pancreatic carcinoma who underwent surgical resection were retrospectively reviewed. Univariate and multivariate models were used to analyze the effect of various clinicopathological factors on long-term survival. There were no operative deaths. Overall 1-, 2-, and 5-year survival rates were 59, 28, and 7%, respectively (median survival time, 12.1 months). Univariate analysis revealed that postoperative adjuvant chemotherapy, portal vein invasion, lymph node metastasis, extrapancreatic nerve plexus invasion, surgical margin status, UICC pT factor, and UICC stage were significantly associated with long-term survival (P < 0.01). Furthermore, use of postoperative adjuvant chemotherapy and absence of extrapancreatic nerve plexus invasion were found to be significant independent predictors of a favorable prognosis using a Cox proportional hazard regression model (P < 0.05). These results suggest that postoperative adjuvant chemotherapy may improve survival after surgical resection for pancreatic carcinoma and that extrapancreatic nerve plexus invasion indicates a poor prognosis for long-term survival.

Postoperative adjuvant chemotherapy improves survival after surgical resection for pancreatic carcinoma. Publishing Authors By Initials

Y Murakami,K Uemura,T Sudo,Y Hayashidani,Y Hashimoto,H Ohge,T Sueda,

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Postoperative adjuvant chemotherapy improves survival after surgical resection for pancreatic carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of gastrointestinal surgery : official jou

VOLUME: 12

Page Numbers: 534-41

Journal Abbreviation: J. Gastrointest. Surg.

ISSN: 1091-255X

DAY: 17

MONTH: 11

YEAR: 2007

Postoperative adjuvant chemotherapy improves survival after surgical resection for pancreatic carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 9706084

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AFFILIATION: Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan, mura777@hiroshima-u.ac.jp.

Country: United States

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MEDLINETA: J Gastrointest Surg

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