Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus.

Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus. Research Abstract Details 

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Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus. Abstract Text:

Sandra M Mooney,Michael W Miller,

Most CNS systems, including the trigeminal-somatosensory system, develop via a hierarchical order (from the periphery and up the neuraxis). We tested the hypothesis that development of the trigeminal system can proceed via a nonhierarchical mechanism (i.e., that neuronogenesis can occur postnatally). Preweanling rats were perfused, and brain sections were stained with cresyl violet or immunolabeled with NeuN (for neuronal counts), or processed for acetylcholinesterase (AChE) activity or p75 immunoreactivity [to identify boundaries of the ventrobasal nucleus (VB)]. Neuronal number decreased during the first postnatal week but increased 2.5-fold over the next 3 weeks. To determine whether this remarkable rise resulted from the generation of new neurons, preweanlings were given injections of bromodeoxyuridine (BrdU) on postnatal day 6 (P6) or P21. BrdU-positive VB cells were apparent on both days. Cumulative BrdU labeling showed that the cell cycle was 17.3 h on P6. Moreover, Ki-67, a protein elaborated throughout the cell cycle, was expressed by 25.8-29.3% of all VB cells on P6-P15, falling to 7.7% by P21. BrdU-positive VB cells coexpressed neuronal markers: NeuN, HuC/D, microtubule-associated protein 2, and a dextran placed in the somatosensory cortex. Note that postnatal neuronal generation was also evident in other thalamic nuclei (e.g., the lateral geniculate nucleus). Thus, the developing VB experiences two periods of neuronal generation. Prenatal neuronogenesis is part of hierarchical trigeminal-somatosensory development. Postnatal nonhierarchical neuronogenesis is intrathalamic and matches changes in neuromodulatory systems (exemplified by AChE activity and p75) and the arrival of corticothalamic afferents.

Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus. Publishing Authors By Initials

SM Mooney,MW Miller,

For similar nervous system: central nervous system: brain: prosencephalon: diencephalon: thalamus: thalamic nuclei: ventral thalamic nuclei research abstracts see: nervous system: central nervous system: brain: prosencephalon: diencephalon: thalamus: thalamic nuclei: ventral thalamic nuclei research

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Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 5023-32

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 9

MONTH: May

YEAR: 2007

Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus. Keywords Mesh Terms:

KEYWORDS: Ventral Thalamic Nuclei

MESH TERMS: metabolism

Chemical & Substance for Abstract: Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus. Information

Substance Name: Acetylcholinesterase

Registry Number: EC 3.1.1.7

Grant and Affiliation Information for Postnatal generation of neurons in the ventrobasal nucleus of the rat thalamus.

AFFILIATION: Department of Neuroscience and Physiology, State University of New York-Upstate Medical University, Syracuse, New York 13210, USA. mooneys@upstate.edu

Country: United States

AGENCY: United States NIAAA

GRANT: AA07568

ACRONYM: AA

MEDLINETA: J Neurosci

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