Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex.

Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Research Abstract Details 

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Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Abstract Text:

S Deshmukh,K Onozuka,K J Bender,V A Bender,B Lutz,K Mackie,D E Feldman,

Endocannabinoids are powerful modulators of synaptic transmission that act on presynaptic cannabinoid receptors. Cannabinoid receptor type 1 (CB1) is the dominant receptor in the CNS, and is present in many brain regions, including sensory cortex. To investigate the potential role of CB1 receptors in cortical development, we examined the developmental expression of CB1 in rodent primary somatosensory (barrel) cortex, using immunohistochemistry with a CB1-specific antibody. We found that before postnatal day (P) 6, CB1 receptor staining was present exclusively in the cortical white matter, and that CB1 staining appeared in the gray matter between P6 and P20 in a specific laminar pattern. CB1 staining was confined to axons, and was most prominent in cortical layers 2/3, 5a, and 6. CB1 null (-/-) mice showed altered anatomical barrel maps in layer 4, with enlarged inter-barrel septa, but normal barrel size. These results indicate that CB1 receptors are present in early postnatal development and influence development of sensory maps.

Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Publishing Authors By Initials

S Deshmukh,K Onozuka,KJ Bender,VA Bender,B Lutz,K Mackie,DE Feldman,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: parietal lobe: somatosensory cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: parietal lobe: somatosensory cortex research

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MEDLINE DATE:

Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience

VOLUME: 145

Page Numbers: 279-87

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 8

MONTH: 01

YEAR: 2007

Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605074

Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Keywords Mesh Terms:

KEYWORDS: Somatosensory Cortex

MESH TERMS: metabolism

Chemical & Substance for Abstract: Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex. Information

Substance Name: Receptor, Cannabinoid, CB1

Registry Number: 0

Grant and Affiliation Information for Postnatal development of cannabinoid receptor type 1 expression in rodent somatosensory cortex.

AFFILIATION: Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, LA Jolla, CA 92093-0357, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS046652-04

ACRONYM: NS

MEDLINETA: Neuroscience

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