Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae.

Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae. Abstract Text:

Y Yuyama,K Yoshimatsu,E Ono,M Saito,M Naiki,

Enterotoxigenic Escherichia coli possessing K99 fimbriae (E. coli K99) causes diarrhea in piglets of less than 1 week old. The first stage of the bacterial infection is adhesion by the fimbriae on the small intestinal mucosa and the adhesion is followed by colony formation. K99 fimbriae bind specifically to N-glycolylneuraminyl-lactosyl-ceramide, GM3(NeuGc) [Ono, E. et al. (1989) Infect. Immun. 57,907-911]. We examined the postnatal change of the content and the molecular species of GM3(NeuGc) in the small intestinal mucosa of 0- to 14-day-old piglets and adult pigs. GM3(NeuGc) was a major ganglioside of piglet intestinal mucosa. GM3(NeuGc) content was maximal at birth and gradually decreased to 1/16 in adult animals (5 months old). The ceramide moiety of piglet intestinal GM3(NeuGc) was characterized by the presence of 2-hydroxylated palmitic acid. 125I-labeled bacteria strongly bound to GM3(NeuGc) containing 2-hydroxylated palmitic acid and phytosphingosine compared with GM3(NeuGc) containing any other ceramide moiety. The time when this particular GM3(NeuGc) appears coincides with the time that the infection occurs, and it may explain the susceptibility of newborn piglets to E. coli K99 infection.

Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae. Publishing Authors By Initials

Y Yuyama,K Yoshimatsu,E Ono,M Saito,M Naiki,

For similar animals: chordata: vertebrates: mammals: artiodactyla: swine research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: swine research

PUBMED ID PMID:

MEDLINE DATE:

Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 113

Page Numbers: 488-92

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Apr

YEAR: 1993

Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: microbiology

Chemical & Substance for Abstract: Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae. Information

Substance Name: N-glycolylneuraminyllactosylceramide

Registry Number: 69345-49-9

Grant and Affiliation Information for Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae.

AFFILIATION: Faculty of Veterinary Medicine, Hokkaido University.

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae Related Publications

• Avian antisera to various gangliosides: detection by enzyme immunoassay.
• Characterization of N-glycolyneuraminic acid-containing glycosphingolipids from a Marek's disease lymphoma-derived chicken cell line, MSB1, as tumor-associated heterophile Hanganutziu-Deicher antigens.
• Establishment of lymphoid cell lines from persons with different P blood group phenotypes and the biosynthesis of the antigenic glycosphingolipids.
• Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast.
• Heterophile antibodies to rabbit erythrocytes in human sera and identification of the antigen as a glycolipid.
• Immunogenicity of N-glycolylneuraminic acid-containing carbohydrate chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells.
• Lysophospholipids induce the nucleation and extension of {beta}2-microglobulin-related amyloid fibrils at a neutral pH.
• O-acetylserine and O-acetylhomoserine sulfhydrylase of yeast; studies with methionine auxotrophs.
• Postnatal change of pig intestinal ganglioside bound by Escherichia coli with K99 fimbriae.
• Sensitive enzyme-immunostaining and densitometric determination on thin-layer chromatography of N-glycolylneuraminic acid-containing glycosphingolipids, Hanganutziu-Deicher antigens.
• Specificities of human heterophile Hanganutziu and Deicher (HD) antibodies to glycosphingolipids and a glycoprotein.
• [Reexamination of radical operation of carcinoma of the esophagus.]