Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?

Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration? Research Abstract Details 

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Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration? Abstract Text:

Ilse Krebs,Werner Brannath,Carl Glittenberg,Florian Zeiler,Jerry Sebag,Susanne Binder,

PURPOSE: To compare the state of the posterior vitreous in exudative age-related macular degeneration (AMD) with eyes with nonexudative AMD and controls. DESIGN: Prospective, observational case series. METHODS: B-scan ultrasonography and optical coherence tomography (OCT) were performed in 163 eyes from 82 subjects older than 55 years, 50 eyes with exudative AMD, 57 with nonexudative AMD, and 56 control eyes. Main outcome measures were the number of eyes with complete posterior vitreous detachment (PVD) by ultrasound and the number of eyes with central vitreomacular adhesion by OCT. RESULTS: By ultrasonography, 17 (34.0%) of 50 eyes with exudative AMD had PVD as compared with 41 (71.9%) of 57 eyes with nonexudative AMD (P = .00002) and 34 (60.7%) of 56 controls (P = .017). OCT detected persistent central vitreoretinal adhesion surrounded by a detached posterior vitreous cortex in 18 (36%) of 50 eyes with exudative AMD, significantly higher than in nonexudative AMD (4/57 [7%]; P < .0001) and in controls (6/56 [10%]; P = .002). CONCLUSIONS: Persistent attachment of the posterior vitreous cortex to the macula may be another risk factor for the development of exudative AMD via vitreoretinal traction inducing chronic low-grade inflammation, by maintaining macular exposure to cytokines or free radicals in the vitreous gel, or by interfering in transvitreous oxygenation and nutrition of the macula. Inducing PVD may provide prophylactic benefit against exudative AMD.

Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration? Publishing Authors By Initials

I Krebs,W Brannath,C Glittenberg,F Zeiler,J Sebag,S Binder,

For similar eye diseases: vitreous detachment research abstracts see: eye diseases: vitreous detachment research

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Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration? Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of ophthalmology

VOLUME: 144

Page Numbers: 741-746

Journal Abbreviation: Am. J. Ophthalmol.

ISSN: 0002-9394

DAY: 20

MONTH: 09

YEAR: 2007

Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration? Information

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LANGUAGE: eng

NlmUniqueID: 370500

Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration? Keywords Mesh Terms:

KEYWORDS: Vitreous Detachment

MESH TERMS: ultrasonography

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Grant and Affiliation Information for Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?

AFFILIATION: Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria. Ilse.Krebs@wienkav.at

Country: United States

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MEDLINETA: Am J Ophthalmol

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