[Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer]

[Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer] Research Abstract Details 

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[Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer] Abstract Text:

Jun-xin Wu,Zhou-guang Hui,Ye-xiong Li,Zi-hao Yu,

OBJECTIVE: To study the effect of post-mastectomy radiotherapy with different fractionated dose schemes for early breast cancer. METHODS: From January 1987 to January 1993, 367 patients with early breast cancer were given post-mastectomy radiotherapy with three different fractionated dose schemes. 149 patients received conventional radiotherapy with 50 Gy/25 fractions/5 weeks (Group A). 177 patients received 45 Gy/15 fractions/5 weeks (Group B). Forty-one patients were treated with 23 Gy/4 fractions/17 days (Group C). 257 patients received systemic therapy (chemotherapy and/or endocrine therapy). RESULTS: The overall 5-year survival and 5-year disease-free survival rates were 87.4% and 89.6%. The 5-year disease-free survival rate were 90.8%, 86.5% and 84.6% for A, B and C groups (P = 0.16). The corresponding loco-regional failure rates were 2.7%, 2.8% and 2.4%, respectively. There was no statistically significant difference in the local control and efficacy of the three groups. CONCLUSION: With similar 5-year tumor-free survival rates by the conventional fractionation and hypofractionation, the scheme with 45 Gy/15 fractions/5 weeks has the advantage of giving less factions, which is suitable for a unit with limited radiation resources. The course of hypofractionation with 23 Gy/4 fractions/17 days is much shorter than conventional radiotherapy, which may benefit patients with higher risk of metastasis who need to undergo chemotherapy earlier. This study warrants further investigations.

[Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer] Publishing Authors By Initials

JX Wu,ZG Hui,YX Li,ZH Yu,

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[Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua zhong liu za zhi [Chinese journal of onco

VOLUME: 25

Page Numbers: 285-8

Journal Abbreviation: Zhonghua Zhong Liu Za Zhi

ISSN: 0253-3766

DAY: 3

MONTH: May

YEAR: 2003

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LANGUAGE: chi

NlmUniqueID: 7910681

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AFFILIATION: Department of Radiation Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.

Country: China

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MEDLINETA: Zhonghua Zhong Liu Za Zhi

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