Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer.

Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Research Abstract Details 

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Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Abstract Text:

Bette J Caan,Jennifer A Emond,Loki Natarajan,Adrienne Castillo,Erica P Gunderson,Laurel Habel,Lovell Jones,Vicky A Newman,Cheryl L Rock,Martha L Slattery,Marcia L Stefanick,Barbara Sternfeld,Cynthia A Thomson,John P Pierce,

PURPOSE: To examine whether weight gain after diagnosis of breast cancer affects the risk of breast cancer recurrence. PATIENT AND METHODS: Patients included 3215 women diagnosed with early stage breast cancer (Stage I >1 cm., II, and IIIA) who were enrolled either in an observational cohort of breast cancer survivors or were part of the comparison group of a dietary intervention trial to prevent breast cancer recurrence. We computed weight change from 1 year prior to diagnosis to study enrollment. Delayed entry Cox proportional hazards models were used to evaluate associations of categories of weight change with time to recurrence, controlling for known prognostic factors. RESULTS: Neither moderate (5-10%) nor large (> 10%) weight gain (HR 0.8, 95% CI, 0.6-1.1; HR 0.9, 95% CI, 0.7-1.2, respectively) after breast cancer diagnosis was associated with an increased risk of breast cancer recurrence in the early years post-diagnosis (median time of 73.7 months from diagnosis). CONCLUSION: Our research provides evidence that weight gain commonly seen in the first several years following a breast cancer diagnosis does not increase a woman's risk for breast cancer recurrence in the first 5-7 years post-diagnosis. However, this research does not address the effects of weight gain on overall survival or on the risk of other new cancers, other prognostic outcomes of concern to the breast cancer survivor.

Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Publishing Authors By Initials

BJ Caan,JA Emond,L Natarajan,A Castillo,EP Gunderson,L Habel,L Jones,VA Newman,CL Rock,ML Slattery,ML Stefanick,B Sternfeld,CA Thomson,JP Pierce,

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Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Breast cancer research and treatment

VOLUME: 99

Page Numbers: 47-57

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ISSN: 0167-6806

DAY: 16

MONTH: 03

YEAR: 2006

Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer.

AFFILIATION: Division of Research, Kaiser Permanente Medical Group, 2000 Broadway, 94612 Oakland, CA, USA. bjc@dor.kaiser.org

Country: Netherlands

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MEDLINETA: Breast Cancer Res Treat

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