Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease.

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease. Abstract Text:

T Fiedler,C ,W Reuter,G Pitre,E Gentz,Hh Schmidt,J ,J Ockenga,T Gerloff,C Meisel,H Lochs,I Roots,K ,A Johne,T Fiedler,C ,W Reuter,G Pitre,E Gentz,H H Schmidt,J ,J Ockenga,T Gerloff,C Meisel,H Lochs,I Roots,K ,A Johne,T Fiedler,C ,W Reuter,G Pitre,E Gentz,H H Schmidt,J ,J Ockenga,T Gerloff,C Meisel,H Lochs,I Roots,K ,A Johne,

BACKGROUND: The role of the single nucleotide polymorphisms (SNPs) on positions 2677G>T/A and 3435C>T of the multi-drug-resistance gene 1 (MDR1) in inflammatory bowel disease (IBD) remains unclear. AIMS: To further elucidate the potential impact of MDR1 two-locus genotypes on susceptibility to IBD and disease behaviour. PATIENTS AND METHODS: Three hundred eighty-eight German IBD patients [244 with Crohn's disease (CD), 144 with ulcerative colitis (UC)] and 1,005 German healthy controls were genotyped for the two MDR1 SNPs on positions 2677G>T/A and 3435C>T. Genotype-phenotype analysis was performed with respect to disease susceptibility stratified by age at diagnosis as well as disease localisation and behaviour. RESULTS: Genotype distribution did not differ between all UC or CD patients and controls. Between UC and CD patients, however, we observed a trend of different distribution of the combined genotypes derived from SNPs 2677 and 3435 (chi(2) = 15.997, df = 8, p = 0.054). In subgroup analysis, genotype frequencies between UC patients with early onset of disease and controls showed significant difference for combined positions 2677 and 3435 (chi(2) = 16.054, df = 8, p = 0.034 for age at diagnosis >/=25, lower quartile). Herein the rare genotype 2677GG/3435TT was more frequently observed (odds ratio = 7.0, 95% confidence interval 2.5 - 19.7). In this group severe course of disease behaviour depended on the combined MDR1 SNPs (chi(2) = 16.101, df = 6, p = 0.017 for age at diagnosis >/=25). No association of MDR1 genotypes with disease subgroups in CD was observed. CONCLUSIONS: While overall genotype distribution did not differ, combined MDR1 genotypes derived from positions 2677 and 3435 are possibly associated with young age onset of UC and severe course of disease in this patient group.

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease. Publishing Authors By Initials

T Fiedler,C ,W Reuter,G Pitre,E Gentz,H Schmidt,J ,J Ockenga,T Gerloff,C Meisel,H Lochs,I Roots,K ,A Johne,T Fiedler,C ,W Reuter,G Pitre,E Gentz,HH Schmidt,J ,J Ockenga,T Gerloff,C Meisel,H Lochs,I Roots,K ,A Johne,T Fiedler,C ,W Reuter,G Pitre,E Gentz,HH Schmidt,J ,J Ockenga,T Gerloff,C Meisel,H Lochs,I Roots,K ,A Johne,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of clinical pharmacology

VOLUME: 63

Page Numbers: 917-25

Journal Abbreviation: Eur. J. Clin. Pharmacol.

ISSN: 0031-6970

DAY: 31

MONTH: 07

YEAR: 2007

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1256165

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease.

AFFILIATION: Department of Gastroenterology, Hepatology & Endocrinology, Charité - Universitätsmedizin Berlin, CCM, Charitéplatz 1, Berlin, 10117, Germany, thomas.fiedler@charite.de.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Clin Pharmacol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease Related Publications

• Detection of a novel circovirus in mute swans (Cygnus olor) by using nested broad-spectrum PCR.
• Detection of hepatitis E virus in archived German wild boar serum samples.
• Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease.
• Search for pharmaceutically interesting quinazoline derivatives: efforts and results (1969-1980).
• Toxic effects of lipopolysaccharide from Bacteroides intermedius and Escherichia coli assessed in the pre-implantation mouse embryo culture system.
• [Experimental and clinical investigations on the combined penicillin-rutin therapy of skin diseases.]
• [Experimental and clinical observations on necrosis of muscle following injection of BAL and sulfactin (Homburg), and its relation to the Sanarelli-Shwartzman phenomenon.]
• [Not Available.]
• [Relation of the Melkersson-Rosenthal syndrome to Miescher's cheilitis granulomatosis.]