Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis.

Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis. Research Abstract Details 

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Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis. Abstract Text:

Transgenic mice carrying the exogenous c-myc gene under regulation of the Ig enhancer (Ig-c-myc) were mated with mice carrying exogenous c-fos gene under control of the H-2Kb promoter (H2-c-fos) to examine their functional collaboration in in vivo lymphomagenesis. Two of the 33 (c-fos x c-myc) mice developed pre-B cell lymphomas within 22 weeks of age. None of the other F1 progeny expressing c-fos or c-myc alone showed malignant change within 14 months of age, suggesting that the exogenous c-fos and c-myc collaborate in in vivo lymphomagenesis. The exogenous c-myc RNA was overexpressed in the lymphomas, but the amount of exogenous c-fos RNA was not affected, suggesting that the large abundance of c-myc protein is a prerequisite for lymphoma onset or progression and c-fos protein plays a complementary role. C-fos protein induced immunodeficiency in the (c-fos x c-myc) mice like H2-c-fos mice. Natural killer cell activity of (c-fos x c-myc) mice was partially impaired. Therefore, these lymphomas may be a consequence of the synergism of two independent actions caused by the exogenous c-myc (lymphomagenesis) and the exogenous c-fos (low NK activity) in (c-fos x c-myc) mice.

Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis. Publishing Authors By Initials

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna research

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Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Kobe journal of medical sciences

VOLUME: 37

Page Numbers: 227-43

Journal Abbreviation: Kobe J Med Sci

ISSN: 0023-2513

DAY: 8

MONTH: Oct

YEAR: 1991

Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis. Information

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LANGUAGE: eng

NlmUniqueID: 413531

Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis. Keywords Mesh Terms:

KEYWORDS: RNA

MESH TERMS: genetics

Chemical & Substance for Abstract: Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis.

AFFILIATION: Department of Immunology, ICMR, Kobe University School of Medicine, Japan.

Country: JAPAN

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MEDLINETA: Kobe J Med Sci

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