Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice.

Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice. Research Abstract Details 

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Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice. Abstract Text:

K Taniguchi,H Ohtani,T Ikemoto,A Miki,S Hori,Y Sawada,K Taniguchi,H Ohtani,T Ikemoto,A Miki,S Hori,Y Sawada,

We present a case of purpura associated with concomitant ingestion of cilostazol, aspirin and grapefruit juice. A 79-year-old man with atherosclerosis obliterans, taking cilostazol and aspirin, complained of purpura. Interview by a pharmacist revealed that he had been taking grapefruit juice for a month. His purpura disappeared upon cessation of grapefruit juice, although his medication was not altered. The most probable cause of his purpura is an increase in the blood level of cilostazol because of the inhibition of cilostazol metabolism by components of grapefruit juice. Aspirin may possibly have potentiated the risk of purpura. Grapefruit juice should be avoided in patients taking cilostazol, especially in patients being concomitantly treated with other anticoagulants.

Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice. Publishing Authors By Initials

K Taniguchi,H Ohtani,T Ikemoto,A Miki,S Hori,Y Sawada,K Taniguchi,H Ohtani,T Ikemoto,A Miki,S Hori,Y Sawada,

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Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 32

Page Numbers: 457-9

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ISSN: 0269-4727

DAY: 18

MONTH: Oct

YEAR: 2007

Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice.

AFFILIATION: Nara Kouseikai Hospital, Nara, Japan.

Country: England

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MEDLINETA: J Clin Pharm Ther

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