Positron detection for the intraoperative localisation of cancer deposits.

Positron detection for the intraoperative localisation of cancer deposits. Research Abstract Details 

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Positron detection for the intraoperative localisation of cancer deposits. Abstract Text:

Morand Piert,Maria Burian, ,Hubert J Stein,Sibylle Ziegler, ,Maria Picchio,Andreas Buck,Joerg R Siewert,Markus Schwaiger,

PURPOSE: The study investigated the feasibility of a positron-sensitive hand-held detector system for the intraoperative localisation of tumour deposits resulting from intravenous [(18)F]FDG administration. METHODS: A total of 17 patients (12 receiving preoperative [(18)F]FDG PET imaging) with various histologically proven malignancies were included. Radioactivity from tumours and surrounding normal tissue was measured on average 3 h after administration of 36-110 MBq [(18)F]FDG and the tumour-to-background (T/B) ratio was calculated. In addition, phantom studies were performed to evaluate the spatial resolution and sensitivity of the probe. RESULTS: All known targeted tumour sites were identified by the positron probe. T/B ratios were generally high, with a mean T/B ratio of 6.6, allowing easy identification of most tumour sites. In one case of a hepatic metastasis, the T/B ratio of 1.34 was below expectations, since the preoperative [(18)F]FDG PET scan was positive. The probe was instrumental in the localisation of three additional tumour lesions (two lymph nodes, one anastomotic ring) that were not immediately apparent at surgery. Phantom studies revealed that [(18)F]FDG-containing gel (simulating tumour tissue), having 10 times more [(18)F]FDG than surrounding "normal" background gel, was clearly detectable in quantities as low as 15 mg. As measured in two cases, the absorbed radiation doses ranged from 2.5 to 8.6 microSv/h for the surgical team to 0.8 microSv/h for the aesthetician. CONCLUSION: [(18)F]FDG-accumulating tumour tissues can be localised with positron probes intraoperatively with a low radiation burden to the patient and medical personnel. The methodology holds promise for further clinical testing.

Positron detection for the intraoperative localisation of cancer deposits. Publishing Authors By Initials

M Piert,M Burian,G ,HJ Stein,S Ziegler,J ,M Picchio,A Buck,JR Siewert,M Schwaiger,

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Positron detection for the intraoperative localisation of cancer deposits. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of nuclear medicine and molecular

VOLUME: 34

Page Numbers: 1534-44

Journal Abbreviation: Eur. J. Nucl. Med. Mol. Imagin

ISSN: 1619-7070

DAY: 12

MONTH: 04

YEAR: 2007

Positron detection for the intraoperative localisation of cancer deposits. Information

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LANGUAGE: eng

NlmUniqueID: 101140988

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Grant and Affiliation Information for Positron detection for the intraoperative localisation of cancer deposits.

AFFILIATION: Department of Nuclear Medicine, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany. mpiert@umich.edu

Country: Germany

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MEDLINETA: Eur J Nucl Med Mol Imaging

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