Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis.

Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis. Research Abstract Details 

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Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis. Abstract Text:

Sara L Sawyer,Harmit S Malik,

Transposable elements have clearly played a major role in shaping both the size and organization of eukaryotic genomes. However, the evolution of essential genes in core biological processes may also have been shaped by coevolution with these elements. This would be predicted to occur in instances where host proteins are either hijacked for use by mobile elements or recruited to defend against them. To detect such cases, we have used the Saccharomyces cerevisiae-Saccharomyces paradoxus sibling species pair to identify genes that have evolved under positive selection. We identify 72 such genes, which participate in a variety of biological processes but are enriched for genes involved in meiosis and DNA repair by nonhomologous end-joining (NHEJ). We confirm the signature of positive selection acting on NHEJ genes using orthologous sequences from all seven Saccharomyces sensu stricto species. Previous studies have found altered rates of Ty retrotransposition when these NHEJ genes are disrupted. We propose that the evolution of these repair proteins is likely to have been shaped by their interactions with Ty elements. Antagonistic pleiotropy, where critical genes like those involved in DNA repair are also subject to selective pressures imposed by mobile elements, could favor alleles that might be otherwise deleterious for their normal roles related to genome stability.

Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis. Publishing Authors By Initials

SL Sawyer,HS Malik,

For similar genetic processes: selection (genetics) research abstracts see: genetic processes: selection (genetics) research

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Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 17614-9

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 13

MONTH: 11

YEAR: 2006

Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis. Keywords Mesh Terms:

KEYWORDS: Selection (Genetics)

MESH TERMS: genetics

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Substance Name: Retroelements

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Grant and Affiliation Information for Positive selection of yeast nonhomologous end-joining genes and a retrotransposon conflict hypothesis.

AFFILIATION: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Country: United States

AGENCY: United States NCI

GRANT: 5 T32 CA10957

ACRONYM: CA

MEDLINETA: Proc Natl Acad Sci U S A

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