Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP.

Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP. Research Abstract Details 

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Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP. Abstract Text:

K Kawabata,K Tashiro,F Sakurai,N Osada,J Kusuda,T Hayakawa,K Yamanishi,H Mizuguchi,K Kawabata,K Tashiro,F Sakurai,N Osada,J Kusuda,T Hayakawa,K Yamanishi,H Mizuguchi,

Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily and a component of epithelial tight junction. CAR also functions as a primary receptor for coxsackievirus B and adenovirus (Ad) infection. In this study, we report the identification of a novel protein, CAR-like soluble protein (CLSP), which is closely related to CAR. Mouse CLSP (mCLSP) was composed of 390 amino acids, including three Ig domains, and showed strong homology to the IgV domain of CAR. Interestingly, mCLSP lacks a transmembrane domain, indicating that this is a soluble protein. mCLSP mRNA was detected primarily in the brain and ovary. When mCLSP cDNA was introduced into SK HEP-1 cells, which were known to be CAR positive and easily infected with Ad vector, the infection with Ad vector was severely inhibited. On the other hand, mCLSP promoted the infection with Ad vector in CAR-negative NIH3T3 cells. Furthermore, recombinant CLSP directly bound to Ad and inhibited the Ad vector-mediated transduction in SK HEP-1 cells. Computational analysis for a genome database showed that the CLSP gene is rodent-specific, and that human and bovine lack this gene. These results suggest that CLSP may play a role in the antiviral defense of the host in rodent animals.

Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP. Publishing Authors By Initials

K Kawabata,K Tashiro,F Sakurai,N Osada,J Kusuda,T Hayakawa,K Yamanishi,H Mizuguchi,K Kawabata,K Tashiro,F Sakurai,N Osada,J Kusuda,T Hayakawa,K Yamanishi,H Mizuguchi,

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Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gene therapy

VOLUME: 14

Page Numbers: 1199-207

Journal Abbreviation: Gene Ther.

ISSN: 0969-7128

DAY: 31

MONTH: 05

YEAR: 2007

Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP. Information

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LANGUAGE: eng

NlmUniqueID: 9421525

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Grant and Affiliation Information for Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP.

AFFILIATION: Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation, Osaka, Japan.

Country: England

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MEDLINETA: Gene Ther

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