Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing.

Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. Research Abstract Details 

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Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. Abstract Text:

William W Hope,Nita L Seibel,Cindy L Schwartz,Antonio Arrieta,Patricia Flynn,Aziza Shad,Edythe Albano,James J Keirns,Donald N Buell,Tawanda Gumbo,George L Drusano,Thomas J Walsh,

The echinocandins potentially have an important role in treatment of infections caused by Candida spp. and Aspergillus spp. in immunocompromised children. However, there are no population pharmacokinetic models of the echinocandins for pediatric patients. The safety and descriptive pharmacokinetics of micafungin in children were recently reported. However, a population pharmacokinetic model in children is needed in order to accurately determine the dosage of micafungin that produces an equivalent magnitude of drug exposure to that observed in adults. In order to explore the effect of weight on micafungin pharmacokinetics, a standard two-compartment pharmacokinetic model, a linear model, and an allometric power model were developed. For all three models, the fit to the data was excellent, with comparable measures of precision and bias. However, the superior log-likelihood value of the allometric power model suggested that it best reflected the data and was therefore chosen for a more detailed analysis of the magnitude and pattern of drug exposure which develop following the administration of micafungin. The allometric power model suggested that clearance in smaller children is higher than that predicted on the basis of weight alone. Consequently, a degree of dosage increase is required in smaller children to ensure comparable levels of drug exposure to those observed in larger children and adults. The allometric power model developed in this study enables identification of pediatric dosage regimens of micafungin which, based upon Monte Carlo simulations, result in equivalent drug exposures to those observed in adults, for which antifungal efficacy has been established.

Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. Publishing Authors By Initials

WW Hope,NL Seibel,CL Schwartz,A Arrieta,P Flynn,A Shad,E Albano,JJ Keirns,DN Buell,T Gumbo,GL Drusano,TJ Walsh,

For similar population characteristics: population research abstracts see: population characteristics: population research

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Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Antimicrobial agents and chemotherapy

VOLUME: 51

Page Numbers: 3714-9

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 16

MONTH: 07

YEAR: 2007

Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 315061

Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. Keywords Mesh Terms:

KEYWORDS: Population

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. Information

Substance Name: micafungin

Registry Number: 0

Grant and Affiliation Information for Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing.

AFFILIATION: Pediatric Oncology Branch, NCI/NIH, CRC Room 1-5750, Bethesda, MD 20892-1100, USA.

Country: United States

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MEDLINETA: Antimicrob Agents Chemother

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