Population-based sample reveals gene-gender interactions in blood pressure in White Americans.

Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Research Abstract Details 

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Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Abstract Text:

Brinda K Rana,Paul A Insel,Samuel H Payne,Kenneth Abel,Ernest Beutler,Michael G Ziegler,Nicholas J Schork,Daniel T O'Connor,

The influence of genetic contributors, such as common single nucleotide polymorphisms, on blood pressure and essential hypertension may vary with the gender. We used the power of a large, community-based sample to probe whether gender interacts with genes in contributing to extremes of blood pressure in 611 male and 656 female age-matched white Americans within the top and bottom 5th percentiles of blood pressure among >53 000 people in a health maintenance program. This approach has >90% statistical power to detect genes contributing as little as 3% to trait (blood pressure) variation. We scored approximately 60 000 genotypes in the subjects: 48 single nucleotide polymorphisms at 33 autosomal and 2 X-linked genes in adrenergic and renal pathways that regulate blood pressure. Six individual variants significantly affected blood pressure and demonstrated gene-by-gender interaction, yielding different effects of the single nucleotide polymorphism on blood pressure in males and females. In females, polymorphisms at beta(1)-adrenergic receptor and alpha(2A)-adrenergic receptor contributed to blood pressure, whereas in men, polymorphisms at beta(2)-adrenergic receptor and angiotensinogen were associated. An alpha(2A)-adrenergic receptor haplotype influenced blood pressure in women, whereas 2 angiotensinogen haplotypes were associated in men. We also detected gene-by-gene, gender-specific interactions (epistasis) in pathophysiological pathways. This study reveals gender-specific effects of single nucleotide polymorphisms, haplotypes, and gene-by-gene interactions that determine blood pressure in white Americans. Such genetic variants may define genetically and etiologically distinct subgroups of men and women with essential hypertension and may have implications for rational treatment selection.

Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Publishing Authors By Initials

BK Rana,PA Insel,SH Payne,K Abel,E Beutler,MG Ziegler,NJ Schork,DT O'Connor,

For similar geographic locations: americas: north america: united states research abstracts see: geographic locations: americas: north america: united states research

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Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Hypertension

VOLUME: 49

Page Numbers: 96-106

Journal Abbreviation: Hypertension

ISSN: 1524-4563

DAY: 11

MONTH: 12

YEAR: 2006

Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906255

Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: genetics

Chemical & Substance for Abstract: Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Information

Substance Name: Angiotensinogen

Registry Number: 11002-13-4

Grant and Affiliation Information for Population-based sample reveals gene-gender interactions in blood pressure in White Americans.

AFFILIATION: Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR00827

ACRONYM: RR

MEDLINETA: Hypertension

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