Polysialic acid in the plasticity of the developing and adult vertebrate nervous system.

Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Research Abstract Details 

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Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Abstract Text:

Urs Rutishauser,Urs Rutishauser,

Polysialic acid (PSA) is a cell-surface glycan with an enormous hydrated volume that serves to modulate the distance between cells. This regulation has direct effects on several cellular mechanisms that underlie the formation of the vertebrate nervous system, most conspicuously in the migration and differentiation of progenitor cells and the growth and targeting of axons. PSA is also involved in a number of plasticity-related responses in the adult CNS, including changes in circadian and hormonal patterns, adaptations to pain and stress, and aspects of learning and memory. The ability of PSA to increase the plasticity of neural cells is being exploited to improve the repair of adult CNS tissue.

Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Publishing Authors By Initials

U Rutishauser,U Rutishauser,

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Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature reviews. Neuroscience

VOLUME: 9

Page Numbers: 26-35

Journal Abbreviation: Nat. Rev. Neurosci.

ISSN: 1471-0048

DAY: 20

MONTH: Jan

YEAR: 2008

Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Polysialic acid in the plasticity of the developing and adult vertebrate nervous system.

AFFILIATION: Department of Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA. rutishau@mskcc.org

Country: England

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MEDLINETA: Nat Rev Neurosci

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