Polyomavirus BK non-coding control region rearrangements in health and disease.

Polyomavirus BK non-coding control region rearrangements in health and disease. Research Abstract Details 

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Polyomavirus BK non-coding control region rearrangements in health and disease. Abstract Text:

Preety M Sharma,Gaurav Gupta,Abhay Vats,Ron Shapiro,Parmjeet S Randhawa,

BACKGROUND: BK virus is an increasingly recognized pathogen in transplanted patients. DNA sequencing of this virus shows considerable genomic variability. METHODS: To understand the clinical significance of rearrangements in the non-coding control region (NCCR) of BK virus (BKV), we report a meta-analysis of 507 sequences, including 40 sequences generated in our own laboratory, for associations between rearrangements and disease, tissue tropism, geographic origin, and viral genotype. RESULTS: NCCR rearrangements were less frequent in (a) asymptomatic BKV viruria compared to patients viral nephropathy (1.7% vs. 22.5%), and (b) viral genotype 1 compared to other genotypes (2.4% vs. 11.2%). Rearrangements were commoner in malignancy (78.6%), and Norwegians (45.7%), and less common in East Indians (0%), and Japanese (4.3%). A surprising number of rearranged sequences were reported from mononuclear cells of healthy subjects, whereas most plasma sequences were archetypal. This difference could not be related to potential recombinase activity in lymphocytes, as consensus recombination signal sequences could not be found in the NCCR region. CONCLUSIONS: NCCR rearrangements are neither required nor a sufficient condition to produce clinical disease. BKV nephropathy and hemorrhagic cystitis are not associated with any unique NCCR configuration or nucleotide sequence.

Polyomavirus BK non-coding control region rearrangements in health and disease. Publishing Authors By Initials

PM Sharma,G Gupta,A Vats,R Shapiro,PS Randhawa,

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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Polyomavirus BK non-coding control region rearrangements in health and disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of medical virology

VOLUME: 79

Page Numbers: 1199-207

Journal Abbreviation: J. Med. Virol.

ISSN: 0146-6615

DAY: 3

MONTH: Aug

YEAR: 2007

Polyomavirus BK non-coding control region rearrangements in health and disease. Information

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LANGUAGE: eng

NlmUniqueID: 7705876

Polyomavirus BK non-coding control region rearrangements in health and disease. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: virology

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Grant and Affiliation Information for Polyomavirus BK non-coding control region rearrangements in health and disease.

AFFILIATION: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R0-1 AI 51227

ACRONYM: AI

MEDLINETA: J Med Virol

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