Polymorphisms of interleukin-10 and its receptor and lung function in COPD.

Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Research Abstract Details 

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Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Abstract Text:

J-Q He,K Shumansky,X Zhang,J E Connett,N R Anthonisen,A J Sandford,

Interleukin (IL)-10 is a type-2 T-helper cell cytokine with a broad spectrum of anti-inflammatory actions. Inflammation plays an important role in the pathogenesis of chronic obstructive pulmonary disease. It was hypothesised that single nucleotide polymorphisms (SNPs) of the genes encoding IL-10 (IL10) and the alpha subunit of its receptor (IL10RA) are associated with changes in, or value of, forced expiratory volume in one second (FEV1) in smoking-induced chronic obstructive pulmonary disease. In total, eleven SNPs of IL10 and IL10RA were studied in 586 White subjects, selected from continuous smokers followed for 5 yrs in the Lung Health Study, who showed the fastest (n=280) and slowest (n=306) decline in FEV1. These 11 SNPs were also studied in 1,072 participants exhibiting the lowest (n=538) and highest (n=534) baseline FEV1 at the beginning of the Lung Health Study. No association was found in the primary analyses. Although a subgroup analysis showed that the IL-10 3368A allele was associated with a fast decline in FEV1, the association did not pass correction for multiple comparisons. No gene-gene interaction of IL10 with IL10RA was found. There was no association of polymorphisms of the genes encoding interleukin-10 and the alpha subunit of its receptor with the rate of decline in, or value of, forced expiratory volume in one second in smoking-induced chronic obstructive pulmonary disease.

Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Publishing Authors By Initials

JQ He,K Shumansky,X Zhang,JE Connett,NR Anthonisen,AJ Sandford,

For similar respiratory tract diseases: lung diseases: lung diseases, obstructive: pulmonary disease, chronic obstructive research abstracts see: respiratory tract diseases: lung diseases: lung diseases, obstructive: pulmonary disease, chronic obstructive research

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Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European respiratory journal : official journa

VOLUME: 29

Page Numbers: 1120-6

Journal Abbreviation: Eur. Respir. J.

ISSN: 0903-1936

DAY: 1

MONTH: 03

YEAR: 2007

Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8803460

Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Keywords Mesh Terms:

KEYWORDS: Pulmonary Disease, Chronic Obstructive

MESH TERMS: pathology

Chemical & Substance for Abstract: Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Information

Substance Name: Interleukin-10

Registry Number: 130068-27-8

Grant and Affiliation Information for Polymorphisms of interleukin-10 and its receptor and lung function in COPD.

AFFILIATION: The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia, 1081 Burrard Street Vancouver, BC, V6Z 1Y6, Canada.

Country: Switzerland

AGENCY: United States NHLBI

GRANT: N01-HR-46002

ACRONYM: HR

MEDLINETA: Eur Respir J

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