Polymorphisms of DNA repair genes are risk factors for prostate cancer.

Polymorphisms of DNA repair genes are risk factors for prostate cancer. Research Abstract Details 

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Polymorphisms of DNA repair genes are risk factors for prostate cancer. Abstract Text:

Hiroshi Hirata,Yuji Hinoda,Yuichiro Tanaka,Naoko Okayama,Yutaka Suehiro,Ken Kawamoto,Nobuyuki Kikuno,Shahana Majid,Kaveh Vejdani,Rajvir Dahiya,

DNA repair gene alterations have been shown to cause a reduction in DNA repair capacity. We hypothesised that DNA repair gene polymorphisms may be risk factors for prostate cancer (PC). To test this hypothesis, DNA samples from 165 cases of prostate cancer and healthy controls were analyzed by PCR-RFLP to determine the genotypic frequency of three DNA repair genes (XRCC1, XPC and XRCC7). We found that the frequency of 939Gln variant at XPC Lys939Gln was significantly lower in PC cases (OR=0.39, P=0.016). Haplotype analysis of XRCC1 Arg194Trp (C/T) and Arg399Gln (G/A) revealed that the frequency of the T-A haplotype was significantly higher in PC patients. This is the first report on the studies of XPC and XRCC1 Arg194Trp polymorphisms in PC, and our present data suggest that XPC Lys939Gln and the T-A haplotype of XRCC1 Arg194Trp and Arg399Gln may be risk factors for PC in Japanese.

Polymorphisms of DNA repair genes are risk factors for prostate cancer. Publishing Authors By Initials

H Hirata,Y Hinoda,Y Tanaka,N Okayama,Y Suehiro,K Kawamoto,N Kikuno,S Majid,K Vejdani,R Dahiya,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Polymorphisms of DNA repair genes are risk factors for prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: European journal of cancer (Oxford, England : 1990

VOLUME: 43

Page Numbers: 231-7

Journal Abbreviation: Eur. J. Cancer

ISSN: 0959-8049

DAY: 29

MONTH: 12

YEAR: 2006

Polymorphisms of DNA repair genes are risk factors for prostate cancer. Information

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LANGUAGE: eng

NlmUniqueID: 9005373

Polymorphisms of DNA repair genes are risk factors for prostate cancer. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Polymorphisms of DNA repair genes are risk factors for prostate cancer. Information

Substance Name: X-ray repair cross complementing protein

Registry Number: 0

Grant and Affiliation Information for Polymorphisms of DNA repair genes are risk factors for prostate cancer.

AFFILIATION: Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, United States.

Country: England

AGENCY: United States NIDDK

GRANT: T32DK07790

ACRONYM: DK

MEDLINETA: Eur J Cancer

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