Polymorphisms in the MTHFR and VDR genes and skin cancer risk.

Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Research Abstract Details 

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Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Abstract Text:

Jiali Han,Graham A Colditz,David J Hunter,

Folate and vitamin D have been shown to be influenced by ultraviolet (UV) radiation. UVA radiation can break down plasma folate, whereas vitamin D can be synthesized in UVB-exposed skin. Folate metabolism is involved in DNA synthesis and repair, and vitamin D processes anti-proliferative effects. The functions of both nutrients are implicated in skin carcinogenesis. We evaluated genetic polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) and the vitamin D receptor (VDR) gene (Fok1, Bsm1 and Cdx2) with skin cancer risk in a nested case-control study within the Nurses' Health Study [219 melanoma, 286 squamous cell carcinoma (SCC), 300 basal cell carcinoma (BCC) and 873 controls]. No significant associations were observed for the two MTHFR polymorphisms on skin cancer risk. We observed an interaction between the C677T polymorphism and total folate intake on SCC risk (P, interaction=0.04); the highest risk was observed among women with TT genotype and low folate intake (OR=2.14; 95% CI=1.01-4.50). The VDR Bsm1 BB genotype was significantly associated with an increased SCC risk (OR=1.51; 95% CI=1.00-2.28). An interaction between the Bsm1 polymorphism and total vitamin D intake on SCC was observed, with the highest risk seen in women with the BB genotype and high vitamin D intake (OR=2.38; 95% CI=1.22-4.62) (P, interaction=0.08). This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC. Due to a large number of comparisons and tests, the possible associations should be interpreted with caution and confirmed by other studies.

Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Publishing Authors By Initials

J Han,GA Colditz,DJ Hunter,

For similar neoplasms: neoplasms by site: skin neoplasms research abstracts see: neoplasms: neoplasms by site: skin neoplasms research

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Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Carcinogenesis

VOLUME: 28

Page Numbers: 390-7

Journal Abbreviation: Carcinogenesis

ISSN: 0143-3334

DAY: 31

MONTH: 08

YEAR: 2006

Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008055

Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Keywords Mesh Terms:

KEYWORDS: Skin Neoplasms

MESH TERMS: genetics

Chemical & Substance for Abstract: Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Information

Substance Name: Methylenetetrahydrofolate Reductase (NAD

Registry Number: EC 1.5.1.20

Grant and Affiliation Information for Polymorphisms in the MTHFR and VDR genes and skin cancer risk.

AFFILIATION: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. jiali.han@channing.harvard.edu

Country: England

AGENCY: United States NCI

GRANT: CA87969

ACRONYM: CA

MEDLINETA: Carcinogenesis

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