Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk.

Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Abstract Text:

Katherine D Crew,Marilie D Gammon,Mary Beth Terry,Fang Fang Zhang,Lydia B Zablotska,Meenakshi Agrawal,Jing Shen,Chang-Min Long,Sybil M Eng,Sharon K Sagiv,Susan L Teitelbaum,Alfred I Neugut,Regina M Santella,Katherine D Crew,Marilie D Gammon,Mary Beth Terry,Fang Fang Zhang,Lydia B Zablotska,Meenakshi Agrawal,Jing Shen,Chang-Min Long,Sybil M Eng,Sharon K Sagiv,Susan L Teitelbaum,Alfred I Neugut,Regina M Santella,Katherine D Crew,Marilie D Gammon,Mary Beth Terry,Fang Fang Zhang,Lydia B Zablotska,Meenakshi Agrawal,Jing Shen,Chang-Min Long,Sybil M Eng,Sharon K Sagiv,Susan L Teitelbaum,Alfred I Neugut,Regina M Santella,

Genes involved in the nucleotide excision repair (NER) pathway, which removes bulky DNA adducts, are potential low-penetrance cancer susceptibility genes. We recently reported an association between detectable polycyclic aromatic hydrocarbon (PAH)-DNA adducts and breast cancer risk. Using a population-based breast cancer case-control study on Long Island, New York, we examined whether polymorphisms in NER genes modified the association between PAH-DNA adducts and breast cancer risk. We examined polymorphisms in ERCC1 (3'-untranslated region 8092C/A), XPA (5'-untranslated region -4G/A), XPD (Asp(312)Asn in exon 10), XPF (Arg(415)Gln in exon 8), and XPG (Asp(1104)His in exon 15) in 1,053 breast cancer cases and 1,102 population-based controls. The presence of at least one variant allele in XPD was associated with a 25% increase in the odds ratio [OR, 1.25; 95% confidence interval (95% CI), 1.04-1.50] for breast cancer. The increase associated with homozygosity of the variant alleles for XPD and ERCC1 was stronger among those with detectable PAH-DNA adduct levels (OR, 1.83; 95% CI, 1.22-2.76 and OR, 1.92; 95% CI, 1.14-3.25 for detectable versus nondetectable adducts and homozygous wild-type genotype for XPD and ERCC1, respectively). We found no association between XPA, XPF, and XPG genotypes, PAH-DNA adducts, and breast cancer risk. When we combined genotypes for these NER pathway genes, there was a significant trend for increasing breast cancer risk with increasing number of putative high-risk alleles. Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in NER pathway genes and detectable PAH-DNA adducts.

Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Publishing Authors By Initials

KD Crew,MD Gammon,MB Terry,FF Zhang,LB Zablotska,M Agrawal,J Shen,CM Long,SM Eng,SK Sagiv,SL Teitelbaum,AI Neugut,RM Santella,KD Crew,MD Gammon,MB Terry,FF Zhang,LB Zablotska,M Agrawal,J Shen,CM Long,SM Eng,SK Sagiv,SL Teitelbaum,AI Neugut,RM Santella,KD Crew,MD Gammon,MB Terry,FF Zhang,LB Zablotska,M Agrawal,J Shen,CM Long,SM Eng,SK Sagiv,SL Teitelbaum,AI Neugut,RM Santella,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 2033-41

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 12

MONTH: Oct

YEAR: 2007

Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk.

AFFILIATION: Department of Epidemiology, Mailman School of Public Health, Columbia University, 161 Fort Washington Avenue, New York, NY 10032, USA. kd59@columbia.edu

Country: United States

AGENCY: United States NCI

GRANT: U01 CA/ES66572

ACRONYM: CA

MEDLINETA: Cancer Epidemiol Biomarkers Pr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk Related Publications

• Actin cytoskeleton modulates calcium signaling during maturation of starfish oocytes.
• Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas.
• Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry.
• DNA adducts in human placenta exposed to ambient environment and passive cigarette smoke during pregnancy.
• Double-strand breaks repair in lymphoblastoid cell lines from sisters discordant for breast cancer from the New York site of the BCFR.
• Evaluation of oxidative stress in a group of adolescents exposed to a high level of aflatoxin B1--a multi-center and multi-biomarker study.
• Extraction of DNA from serum for high-throughput genotyping: findings from pilot studies within the prostate cancer prevention trial.
• Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk.
• Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk.
• Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York.
• IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer risk.
• Is correction for protein concentration appropriate for protein adduct dosimetry? Hypothesis and clues from an aflatoxin B1-exposed population.
• No effect of cigarette smoking dose on oxidized plasma proteins.
• PAH, genetic susceptibility and breast cancer risk: An update from the Long Island Breast Cancer Study Project.
• Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study.
• Plasma protein carbonyl levels and breast cancer risk.
• Polycyclic aromatic hydrocarbon- and aflatoxin-albumin adducts, hepatitis B virus infection and hepatocellular carcinoma in Taiwan.
• Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk.
• Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA.
• Short telomere length and breast cancer risk: a study in sister sets.
• Telomere length in hepatocellular carcinoma and paired adjacent non-tumor tissues by quantitative PCR.
• Urinary 15-F2t-isoprostane, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan.
• Urinary 8-oxodeoxyguanosine, aflatoxin B1 exposure and hepatitis B virus infection and hepatocellular carcinoma in Taiwan.
• Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk.