Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption.

Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Research Abstract Details 

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Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Abstract Text:

Cande V Ananth,Denise A Elsasser,Wendy L Kinzler,Morgan R Peltier,Darios Getahun,Daniel Leclerc,Rima R Rozen, ,

OBJECTIVES: Methionine synthase reductase (MTRR) and betaine-homocysteine S-methyltransferase (BHMT) are two enzymes that regulate homocysteine metabolism. Elevated homocysteine (hyperhomocysteinemia) is associated with adverse pregnancy outcomes and vascular disease. We assessed whether polymorphisms in MTRR (66A-->G; I22M) and BHMT (742G-->A; R239Q) were associated with abruption. We further evaluated whether homocysteine levels differed between cases and controls for MTRR and BHMT genotypes. METHODS: Data were derived from the New Jersey Placental Abruption Study (NJ-PAS)-an ongoing, multicenter, case-control study since August 2002. Women with a clinical diagnosis of abruption were recruited as incident cases (n=196), and controls (n=191) were matched to cases based on maternal race/ethnicity and parity. Total plasma homocysteine concentrations were evaluated in a subset of 136 cases and 136 controls. DNA was genotyped for the MTRR and BHMT polymorphisms. RESULTS: Frequencies of the minor allele of MTRR were 40.8% and 42.2% in cases and controls, respectively (adjusted OR 0.79, 95% CI 0.45, 1.40). The corresponding rates for BHMT were 33.9% and 31.7%, respectively (adjusted OR 1.93, 95% CI 0.99, 4.09). Distributions for the homozygous mutant form of MTRR were similar between cases and controls (OR 1.18, 95% CI 0.62, 2.24). The rate of homozygous mutant BHMT genotype was 2.8-fold (OR 2.82, 95% CI 1.84, 4.97) higher in cases than controls. Stratification of analyses based on maternal race did not reveal any patterns in association. CONCLUSIONS: In this population, there was an association between the homozygous mutant form of BHMT (742G-->A) polymorphism and increased risk for placental abruption.

Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Publishing Authors By Initials

CV Ananth,DA Elsasser,WL Kinzler,MR Peltier,D Getahun,D Leclerc,RR Rozen, ,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: azoles: pyrroles: tetrapyrroles: corrinoids: vitamin b 12 research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: azoles: pyrroles: tetrapyrroles: corrinoids: vitamin b 12 research

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Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular genetics and metabolism

VOLUME: 91

Page Numbers: 104-10

Journal Abbreviation:

ISSN: 1096-7192

DAY: 26

MONTH: 03

YEAR: 2007

Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9805456

Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Keywords Mesh Terms:

KEYWORDS: Vitamin B 12

MESH TERMS: blood

Chemical & Substance for Abstract: Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption. Information

Substance Name: Betaine-Homocysteine S-Methyltransferase

Registry Number: EC 2.1.1.5

Grant and Affiliation Information for Polymorphisms in methionine synthase reductase and betaine-homocysteine S-methyltransferase genes: risk of placental abruption.

AFFILIATION: Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901-1977, USA. cande.ananth@umdnj.edu

Country: United States

AGENCY: United States NICHD

GRANT: R01 HD038902-05

ACRONYM: HD

MEDLINETA: Mol Genet Metab

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