Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer.

Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer. Abstract Text:

Ikuko Kato,Federico Canzian,Martyn Plummer,Silvia Franceschi,Leen-Jan van Doorn,Jorge Vivas,Gladys Lopez,Yanhui Lu,Lydie Gioia-Patricola,Richard K Severson,Ann G Schwartz,Nubia ,

As Helicobacter pylori (HP) is a Gram-negative bacterium, we investigated the associations between several functional polymorphisms in genes involved in lipopolysaccharide (LPS) signaling and the prevalence of various stages of gastric premalignant lesions in a Venezuelan population. The two NOD2 polymorphisms, del3020insC and Gly908Arg, were too infrequent to study their associations with gastric lesions. The risk of intestinal metaplasia (IM) was significantly increased among subjects with the CD14 T-260 allele compared to those without this allele. A similar, but nonsignificant increase in risk for dysplasia was observed among homozygotes of this allele. There was no association between TLR4 Asp299Gly polymorphism and any type of lesions, except for a slight nonsignificant increase in risk of IM associated with the AA genotype among subjects with a higher histological HP score. These results suggest that genetic polymorphisms in HP LPS signaling may be implicated in the development of intermediate stages of gastric premalignant lesions.

Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer. Publishing Authors By Initials

I Kato,F Canzian,M Plummer,S Franceschi,LJ van Doorn,J Vivas,G Lopez,Y Lu,L Gioia-Patricola,RK Severson,AG Schwartz,N ,

For similar geographic locations: americas: south america: venezuela research abstracts see: geographic locations: americas: south america: venezuela research

PUBMED ID PMID:

MEDLINE DATE:

Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Digestive diseases and sciences

VOLUME: 52

Page Numbers: 254-61

Journal Abbreviation: Dig. Dis. Sci.

ISSN: 0163-2116

DAY: 14

MONTH: 12

YEAR: 2006

Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7902782

Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer. Keywords Mesh Terms:

KEYWORDS: Venezuela

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer. Information

Substance Name: Toll-Like Receptor 4

Registry Number: 0

Grant and Affiliation Information for Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer.

AFFILIATION: Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, Michigan 48201, USA. katoi@med.wayne.edu

Country: United States

AGENCY: United States NCI

GRANT: CA 98309

ACRONYM: CA

MEDLINETA: Dig Dis Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer Related Publications

• Axial myopathy due to primary amyloidosis.
• Belief about drug assignment and abstinence in treatment of cigarette smoking using nortriptyline.
• Bimodal virological response to antiretroviral therapy for HIV infection: an application using a mixture model with left censoring.
• Comparative study of biosorption of heavy metals using different types of algae.
• Conformational dynamics and ensembles in protein folding.
• Dexmedetomidine: do we know enough?
• Endoscopic-assisted osteotomies for the treatment of craniosynostosis.
• Estimation of the plasma effect-site equilibration rate constant (ke0) of rocuronium by the time of maximum effect: a comparison with non-parametric and parametric approaches.
• Gene organization of the ornithine decarboxylase-encoding region in Morganella morganii.
• Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela.
• Interpersonal factors and perinatal depressive symptomatology in a low-income Latina sample.
• Kluyvera meningitis in a newborn.
• Life threatening parvovirus B19 and herpes simplex virus associated acute myocardial dysfunction in a child with homozygous sickle cell disease.
• Management of medication noncompliance in solid-organ transplant recipients.
• Mycobacterium simiae cervical lymphadenitis.
• On the physical, spectral, and dosimetric characteristics of a new 125I brachytherapy source.
• Parametric survival analysis and taxonomy of hazard functions for the generalized gamma distribution.
• Patients at high risk for ischemic stroke: identification and actions.
• Polymorphisms in genes related to bacterial lipopolysaccharide/peptidoglycan signaling and gastric precancerous lesions in a population at high risk for gastric cancer.
• Preoperative autologous blood donation in Spain (1994-2004).
• Protein folding kinetics: barrier effects in chemical and thermal denaturation experiments.
• Randomized controlled trial of vascular access in newborns in the neonatal intensive care unit.
• Reducing pesticide exposure and associated neurotoxic burden in an Ecuadorian small farm population.
• Roux-en-Y gastric bypass: major complications.
• Structural features of three ureterocele calculi.
• The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells.
• The relationship between alexithymia and perinatal depressive symptomatology.
• [New strategies for a better use of peginterferon and ribavirin and new drugs with specifically-targeted antiviral therapy for chronic hepatitis C]
• [Priorities in health promotion according to primary care health professionals: a Delphi study]
• [The importance of detection and treatment of somatic symptoms in Latin American patients with major depression]