Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques.

Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Research Abstract Details 

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Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Abstract Text:

Andrea Weiler,Gemma E May,Ying Qi,Nancy Wilson,David I Watkins,

Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous control of SIV in any of these animals could be explained by mutations in host genes. Such variables could confound studies of associations between MHC class I alleles and control of viral replication. We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-alpha, and TSG101 and looked for associations with decreased viral replication. We did not detect any correlations between plasma viral concentration and polymorphisms in host genes examined in this study. In addition, we did not find the polymorphisms present in humans in any of our macaques.

Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Publishing Authors By Initials

A Weiler,GE May,Y Qi,N Wilson,DI Watkins,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Immunogenetics

VOLUME: 58

Page Numbers: 1003-9

Journal Abbreviation: Immunogenetics

ISSN: 0093-7711

DAY: 10

MONTH: 11

YEAR: 2006

Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Information

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LANGUAGE: eng

NlmUniqueID: 420404

Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: genetics

Chemical & Substance for Abstract: Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Information

Substance Name: Tsg101 protein

Registry Number: 0

Grant and Affiliation Information for Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques.

AFFILIATION: Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA. amweiler@wisc.edu

Country: United States

AGENCY: United States NCRR

GRANT: R24 RR016038

ACRONYM: RR

MEDLINETA: Immunogenetics

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