Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia.

Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia. Research Abstract Details 

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Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia. Abstract Text:

Jan-Willem Muntjewerff,Henkjan Gellekink,Martin den Heijer,Mechteld L C Hoogendoorn, Kahn,Richard J Sinke,Henk J Blom,

BACKGROUND: Evidence is emerging for the association of aberrant homocysteine-methylation cycle and increased risk of schizophrenia. METHODS: We examined the prevalence of the catechol-O-methyltransferase (COMT) 324G>A (Val108/158Met) and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms in 252 patients with schizophrenia and 405 control subjects. All subjects were of Dutch ancestry. RESULTS: The COMT 324AA genotype was not associated with an increased risk of schizophrenia (odds ratio (OR)=1.38 [95% CI: 0.88-2.16], P=0.162), and the MTHFR 677TT genotype showed a nearly significant increased risk for schizophrenia (OR=1.65 [95% CI: 0.97-2.82], P=0.067). The odds ratio for schizophrenia associated with joint occurrence of the COMT 324AA and MTHFR 677TT genotype was 3.08 (95% CI: 1.08-8.76) (P=0.035). Increasing number of low enzyme activity alleles in the COMT and MTHFR genotype combinations were associated with an increased risk of schizophrenia (test for trend, P=0.017). CONCLUSIONS: Our findings do not support a major role for the COMT 324AA and MTHFR 677TT genotype alone, but the combination of both genotypes might increase schizophrenia susceptibility.

Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia. Publishing Authors By Initials

JW Muntjewerff,H Gellekink,M den Heijer,ML Hoogendoorn,RS Kahn,RJ Sinke,HJ Blom,

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Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European neuropsychopharmacology : the journal of

VOLUME: 18

Page Numbers: 99-106

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ISSN: 0924-977X

DAY: 22

MONTH: 08

YEAR: 2007

Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophrenia. Information

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LANGUAGE: eng

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AFFILIATION: GGz Nijmegen, Mental Health Institute, PO Box 7049, 6503 GM Nijmegen, The Netherlands.

Country: Netherlands

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MEDLINETA: Eur Neuropsychopharmacol

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