Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population.

Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Research Abstract Details 

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Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Abstract Text:

Baorui Liu,Jia Wei,Zhengyun Zou,Xiaoping Qian,Takahiro Nakamura,Wei Zhang,Yitao Ding,Jifeng Feng,Lixia Yu,

Pharmacogenetic advances in cancer chemotherapy have the potential to predict clinical benefit to particular regimens. Platinum agents have shown to be effective in the treatment of gastric cancer. We assessed whether single nucleotide polymorphisms (SNPs) in xeroderma pigmentosum group D (XPD), X-ray repair cross complementing group 1 (XRCC1) and glutathione S-transferase P1 (GSTP1) predicted overall survival in gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. SNPs of XPD-751, XRCC1-399 and GSTP1-105 in 62 gastric cancer patients were evaluated using the TaqMan 5' nuclease assay. Genotypes were correlated to survival. The median overall survival time was 322 days (range: 56-2058 days). The median survival times for patients with Arg/Arg or Arg/Gln genotypes of XRCC1 gene were significantly longer than others (P=0.03). For 58 patients with ECOG PS (Eastern Cooperative Oncology Group performance status)

Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Publishing Authors By Initials

B Liu,J Wei,Z Zou,X Qian,T Nakamura,W Zhang,Y Ding,J Feng,L Yu,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: adenosine triphosphatases: dna helicases: xeroderma pigmentosum group d protein research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: adenosine triphosphatases: dna helicases: xeroderma pigmentosum group d protein research

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Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of human genetics : EJHG

VOLUME: 15

Page Numbers: 1049-53

Journal Abbreviation: Eur. J. Hum. Genet.

ISSN: 1018-4813

DAY: 27

MONTH: 06

YEAR: 2007

Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Information

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LANGUAGE: eng

NlmUniqueID: 9302235

Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Keywords Mesh Terms:

KEYWORDS: Xeroderma Pigmentosum Group D Protein

MESH TERMS: genetics

Chemical & Substance for Abstract: Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population. Information

Substance Name: Xeroderma Pigmentosum Group D Protein

Registry Number: EC 5.99.-

Grant and Affiliation Information for Polymorphism of XRCC1 predicts overall survival of gastric cancer patients receiving oxaliplatin-based chemotherapy in Chinese population.

AFFILIATION: Department of Oncology, Drum Tower Hospital (affiliated to Medical School of Nanjing University) and Clinical Cancer Institute of Nanjing University, Nanjing, China. baoruiliu@nju.edu.cn

Country: England

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MEDLINETA: Eur J Hum Genet

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