Polymorphism of human mucin genes in chest disease: possible significance of MUC2.

Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Research Abstract Details 

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Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Abstract Text:

L E Vinall,J C Fowler,A L Jones,H J Kirkbride,C ,A Laine,N Porchet,J R Gum,Y S Kim,F M Moss,D M Mitchell,D M Swallow,

Most of the genes that encode epithelial mucins are highly polymorphic due to variations in the length of domains of tandemly repeated (TR) coding sequence, the part of the apomucin that is heavily glycosylated. We report here for the first time a difference in the distribution of MUC TR length alleles in chest disease. We examined the distribution of the length alleles of those MUC genes whose expression we have confirmed in the bronchial tree in an age- and sex-matched series of 50 pairs of atopic patients with and without asthma. There was no significant difference in the distribution of alleles of MUC1, MUC4, MUC5AC, and MUC5B. MUC2, however, showed a highly significant difference in distribution. The atopic, nonasthmatic individuals showed an allele distribution that was very different from all our other patient and control groups, this group showing a longer mean allele length. The observations suggest that longer MUC2 alleles may help protect atopic individuals from developing asthma, though the effect may be due to a linked gene. The biological significance of this variation with respect to susceptibility to asthma will merit further investigation, and it will also be important to substantiate this finding on an independent data set.

Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Publishing Authors By Initials

LE Vinall,JC Fowler,AL Jones,HJ Kirkbride,C ,A Laine,N Porchet,JR Gum,YS Kim,FM Moss,DM Mitchell,DM Swallow,

For similar genetic phenomena: variation (genetics): polymorphism, genetic research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic research

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Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of respiratory cell and molecular

VOLUME: 23

Page Numbers: 678-86

Journal Abbreviation: Am. J. Respir. Cell Mol. Biol.

ISSN: 1044-1549

DAY: 30

MONTH: Nov

YEAR: 2000

Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Information

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LANGUAGE: eng

NlmUniqueID: 8917225

Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Information

Substance Name: Neoplasm Proteins

Registry Number: 0

Grant and Affiliation Information for Polymorphism of human mucin genes in chest disease: possible significance of MUC2.

AFFILIATION: MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, London, United Kingdom.

Country: UNITED STATES

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MEDLINETA: Am J Respir Cell Mol Biol

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