Polymorphism in the human C-reactive protein (CRP) gene, serum concentrations of CRP, and the difference between intracranial and extracranial atherosclerosis.

Polymorphism in the human C-reactive protein (CRP) gene, serum concentrations of CRP, and the difference between intracranial and extracranial atherosclerosis. Research Abstract Details 

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Polymorphism in the human C-reactive protein (CRP) gene, serum concentrations of CRP, and the difference between intracranial and extracranial atherosclerosis. Abstract Text:

Zhi-Zhong Liu,Hong Lv,Feng Gao,Gang Liu,Hua-Guang Zheng,Ya-Li Zhou,Ya-Jie Wang,Xi-Xiong Kang,Zhi-Zhong Liu,Hong Lv,Feng Gao,Gang Liu,Hua-Guang Zheng,Ya-Li Zhou,Ya-Jie Wang,Xi-Xiong Kang,

BACKGROUND: C-reactive protein, a proinflammatory factor, is involved in the development of atherosclerosis. The CRP 1059G>C polymorphism appeared to be a susceptive marker for atherosclerosis. We investigated the relationship of the distribution of cerebral atherosclerosis with triggered serum CRP concentrations following acute ischemic stroke/transient ischemic attack (IS/TIA) and CRP 1059G>C polymorphism. METHODS: We recruited 222 IS/TIA patients (122 with only intracranial atherosclerotic lesions and 100 with isolated extracranial atherosclerotic lesions) and 227 controls. Intra- and extracranial atherosclerotic lesions were determined by digital subtraction angiography. Serum CRP concentrations were measured by particle-enhanced immunonephelometry assay. CRP 1059G>C genotypes were obtained through PCR amplification and restriction enzyme digestion. RESULTS: CRP concentrations were significantly higher in intra- and extracranial groups than in controls. No significant difference was found in CRP concentrations between intra- and extracranial groups. The CRP 1059G>C single-nucleotide polymorphism did not influence CRP serum concentrations. CRP genotype and allele frequencies did not differ significantly between patients and controls. However, the frequencies of GC genotype and C allele were significantly higher in extracranial group than that in intracranial group. The GC individuals showed a higher risk of extracranial atherosclerosis compared with GG individuals (OR 3.41; 95%CI, 1.124-10.347; P=0.030). CONCLUSIONS: Serum CRP is associated with cerebral atherosclerotic disease. CRP 1059G>C polymorphism is one possible genetic determinant for the difference between intra- and extracranial atherosclerosis.

Polymorphism in the human C-reactive protein (CRP) gene, serum concentrations of CRP, and the difference between intracranial and extracranial atherosclerosis. Publishing Authors By Initials

ZZ Liu,H Lv,F Gao,G Liu,HG Zheng,YL Zhou,YJ Wang,XX Kang,ZZ Liu,H Lv,F Gao,G Liu,HG Zheng,YL Zhou,YJ Wang,XX Kang,

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Polymorphism in the human C-reactive protein (CRP) gene, serum concentrations of CRP, and the difference between intracranial and extracranial atherosclerosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinica chimica acta; international journal of cli

VOLUME: 389

Page Numbers: 40-4

Journal Abbreviation: Clin. Chim. Acta

ISSN: 0009-8981

DAY: 29

MONTH: 11

YEAR: 2007

Polymorphism in the human C-reactive protein (CRP) gene, serum concentrations of CRP, and the difference between intracranial and extracranial atherosclerosis. Information

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LANGUAGE: eng

NlmUniqueID: 1302422

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Grant and Affiliation Information for Polymorphism in the human C-reactive protein (CRP) gene, serum concentrations of CRP, and the difference between intracranial and extracranial atherosclerosis.

AFFILIATION: The Center for Laboratory Diagnosis, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China.

Country: Netherlands

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MEDLINETA: Clin Chim Acta

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