Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses.

Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses. Research Abstract Details 

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Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses. Abstract Text:

Simard,Monica Licht,Nora J Besansky,Tovi Lehmann,

Genetic variation in defensin, a gene encoding a major effector molecule of insects immune response was analyzed within and between populations of three members of the Anopheles gambiae complex. The species selected included the two anthropophilic species, An. gambiae and An. arabiensis and the most zoophilic species of the complex, An. quadriannulatus. The first species was represented by four populations spanning its extreme genetic and geographical ranges, whereas each of the other two species was represented by a single population. We found (i) reduced overall polymorphism in the mature peptide region and in the total coding region, together with specific reductions in rare and moderately frequent mutations (sites) in the coding region compared with non-coding regions, (ii) markedly reduced rate of non-synonymous diversity compared with synonymous variation in the mature peptide and virtually identical mature peptide across the three species, and (iii) increased divergence between species in the mature peptide together with reduced differentiation between populations of An. gambiae in the same DNA region. These patterns suggest a strong purifying selection on the mature peptide and probably the whole coding region. Because An. quadriannulatus is not exposed to human pathogens, identical mature peptide and similar pattern of polymorphism across species implies that human pathogens played no role as selective agents on this peptide.

Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses. Publishing Authors By Initials

F Simard,M Licht,NJ Besansky,T Lehmann,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Infection, genetics and evolution : journal of mol

VOLUME: 7

Page Numbers: 285-92

Journal Abbreviation: Infect. Genet. Evol.

ISSN: 1567-1348

DAY: 8

MONTH: 12

YEAR: 2006

Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses. Information

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LANGUAGE: eng

NlmUniqueID: 101084138

Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses. Information

Substance Name: Defensins

Registry Number: 0

Grant and Affiliation Information for Polymorphism at the defensin gene in the Anopheles gambiae complex: testing different selection hypotheses.

AFFILIATION: Organisation de Coordination pour la lutte Contre les Endémies en Afrique Centrale (OCEAC), BP 288, Yaoundé, Cameroon. simard@ird.fr

Country: Netherlands

AGENCY: United States PHS

GRANT: 001-1903-571

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MEDLINETA: Infect Genet Evol

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